Journal of the American Academy of Dermatology
Volume 54, Issue 4 , Pages 709-711, April 2006

Induction of withdrawal-like symptoms in a small randomized, controlled trial of opioid blockade in frequent tanners

  • Mandeep Kaur, MD

      Affiliations

    • From the Center for Dermatology Research, Departments of Dermatology
    • ,
  • Anthony Liguori, PhD

      Affiliations

    • Physiology/Pharmacology
    • ,
  • Wei Lang, PhD

      Affiliations

    • Public Health Sciences
    • ,
  • Stephen R. Rapp, PhD

      Affiliations

    • Public Health Sciences
    • Psychiatry and Behavioral Medicine
    • ,
  • Alan B. Fleischer Jr., MD

      Affiliations

    • From the Center for Dermatology Research, Departments of Dermatology
    • ,
  • Steven R. Feldman, MD, PhD

      Affiliations

    • From the Center for Dermatology Research, Departments of Dermatology
    • Public Health Sciences
    • Pathology, Wake Forest University School of Medicine
    • Corresponding Author InformationReprint requests: Steven R. Feldman, MD, PhD, Department of Dermatology, Wake Forest University School of Medicine, Medical Center Boulevard, Winston-Salem, NC 27157-1071.

Winston-Salem, North Carolina

Frequent tanning has reinforcing properties. We tested whether opioid antagonism blocks potential reinforcing effect of indoor tanning in 8 frequent tanners and 8 infrequent tanner control subjects. Opioid blockade reduced ultraviolet preference in frequent tanners. Four of 8 frequent tanners, but no infrequent tanners, exhibited withdrawal-like symptoms with naltrexone administration. A limitation of this study is its small size.

 

 Funding sources: The Center for Dermatology Research is supported by a grant from Galderma Laboratories, L.P. This study was supported by a grant from the National Institutes of Health (DA14014-01) and by a pilot grant from the Wake Forest University Women's Health Center of Excellence.Conflicts of interest: None identified.

PII: S0190-9622(05)04601-3

doi:10.1016/j.jaad.2005.11.1059

Journal of the American Academy of Dermatology
Volume 54, Issue 4 , Pages 709-711, April 2006