Journal of the American Academy of Dermatology
Volume 48, Issue 6 , Pages 836-845 , June 2003

Efficacy and safety of azelaic acid (15%) gel as a new treatment for papulopustular rosacea: Results from two vehicle-controlled, randomized phase III studies

Presented in abstract form at the 61st Annual Meeting of the American Academy of Dermatology, San Francisco, California, March 21-26, 2003.

,Accepted 3 January 2003.

References 

  1. Wilkin JK. Rosacea: pathophysiology and treatment. Arch Dermatol. 1994;130:359–362
  2. Wilkin J, Dahl M, Detmar M, Drake L, Feinstein A, Odom R, et al.  Standard classification of rosacea: report of the National Rosacea Society expert committee on the classification and staging of rosacea. J Am Acad Dermatol. 2002;46:584–587
  3. Rebora A. The management of rosacea. Am J Clin Dermatol. 2002;3:489–496
  4. Maddin S. A comparison of topical azelaic acid 20% cream and topical metronidazole 0.75% cream in the treatment of patients with papulopustular rosacea. J Am Acad Dermatol. 1999;40:961–965
  5. Bjerke R, Fyrand O, Graupe K. Double-blind comparison of azelaic acid 20% cream and its vehicle in treatment of papulopustular rosacea. Acta Derm Venereol. 1999;79:456–459
  6. Carmichael AJ, Mark R, Graupe KA, Zaumseil RP. Topical azelaic acid in the treatment of rosacea. J Dermatol Treat. 1993;4(Suppl):S19–S22
  7. Bergfeld WF. A lifetime of healthy skin: implications for women. Int J Fertil Womens Med. 1999;44:83–95
  8. Passi S. Pharmacology and pharmacokinetics of azelaic acid. Rev Contemp Pharmacother. 1993;4:441–447
  9. Bojar RA, Holland KT. Azelaic acid: a review of its antimicrobial properties. Rev Contemp Pharmacother. 1993;4:403–414
  10. Passi S, Picardo M, Zompetta C, De Luca C, Breathnach AS, Nazzaro-Porro M. The oxyradical-scavenging activity of azelaic acid in biological systems. Free Radic Res Commun. 1991;15:17–28
  11. Akamatsu H, Komura J, Asada Y, Miyachi Y, Niwa Y. Inhibitory effect of azelaic acid on neutrophil functions: a possible cause for its efficacy in treating pathogenetically unrelated diseases. Arch Dermatol Res. 1991;283:162–266
  12. Akamatsu H, Oguchi M, Nishijima S, Asada Y, Takahashi M, Ushijima T, et al.  The inhibition of free radical generation by human neutrophils through the synergistic effects of metronidazole with palmitoleic acid: possible mechanism of action of metronidazole in rosacea and acne. Arch Dermatol Res. 1990;282:449–454
  13. Nazzaro-Porro M, Passi S, Picardo M, Balus L, Breathnach AS. L'acido azelaico nella rosacea?. G Ital Dermatol Venerol. 1991;126:19–27
  14. Thiboutot D. New treatments and therapeutic strategies for acne. Arch Fam Med. 2000;9:179–187
  15. Zuber TJ. Rosacea. Prim Care. 2000;27:309–318

☆ Supported by Berlex Laboratories.

☆☆ Disclosure: Dr Thieroff-Ekerdt is an employee of Berlex Laboratories. Dr Graupe is an employee of Schering AG. Dr Thiboutot received financial compensation from Berlex Laboratories for her role as a principal investigator in these studies.

★ Reprint requests: Diane Thiboutot, MD, Department of Dermatology, Pennsylvania State University College of Medicine, The Milton S. Hershey Medical Center, UPC-2, Room 4300, 500 University Dr, Hershey, PA 17033.

★★ 0190-9622/2003/$30.00 + 0

PII: S0190-9622(03)00405-5

doi: 10.1067/mjd.2003.308

Journal of the American Academy of Dermatology
Volume 48, Issue 6 , Pages 836-845 , June 2003

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