Journal of the American Academy of Dermatology
Volume 53, Issue 1 , Pages 62-66 , July 2005

Cutaneous necrosis after injection of polyethylene glycol–modified interferon alfa

,Accepted 15 February 2005.

References 

  1. Chang LW, Liranzo M, Bergfeld WF. Cutaneous side effects associated with interferon-alpha therapy: a review. Cutis. 1995;56:144
  2. Pfeffer LM, Dinarello CA, Herberman RB, Williams BR, Borden EC, Bordens R, et al. Biological properties of recombinant alpha-interferons: 40th anniversary of the discovery of interferons. Cancer Res. 1998;58:2489–2499
  3. Rogers CJ, Romagosa R, Vincek V. Cutaneous sarcoidosis associated with pegylated interferon alfa and ribavirin therapy in a patient with chronic hepatitis C. J Am Acad Dermatol. 2004;50:649–650
  4. Virgili A, Corazza M, Lombardi AR, Sighinolfi L. Cutaneous ulcers due to interferon seem not to be related to the dosage. J Eur Acad Dermatol Venereol. 1999;13:141–143
  5. Fortuno Y, Marcoval J, Gallego I, Moreno A, Arbizu T, Peyri J. Reacciones cutaáneas por interferón beta en una serie de 92 pacientes con esclerosis múltiple. Med Clin (Barc). 1999;113:447–448
  6. Sasseville D, Ghamdi WA, Khenaizan SA. Interferon-induced cutaneous necrosis. J Cutan Med Surg. 1999;3:320–323
  7. Rasokat H, Bendick C, Wemmer U, Steigleder GK. Aseptic skin necrosis after subcutaneous injection of interferon alpha. Dtsch Med Wochenschr. 1989;114:458–460
  8. Cnudde F, Gharakhanian S, Luboinski J, Dry J, Rozenbaum W. Cutaneous local necrosis following interferon injections. Int J Dermatol. 1991;30:147
  9. Bessis D, Charron A, Rouzier-Panis R, Blatiere V, Guilhou JJ, Reynes J. Necrotizing cutaneous lesions complicating treatment with pegylated-interferon alpha in an HIV-infected patient. Eur J Dermatol. 2002;12:99–102
  10. Sparsa A, Loustaud-Ratti V, Liozon E, Denes E, Soria P, Bouyssou-Gauthier ML, et al. Réactions cutanées ou nécrose à l'interféron alpha: peut-on reprendre l'interféron? À propos de six cas. Rev Med Interne. 2000;21:756–763
  11. Heinzerling L, Dummer R, Wildberger H, Burg G. Cutaneous ulceration after injection of polyethylene-glycol-modified interferon alpha associated with visual disturbances in a melanoma patient. Dermatology. 2000;201:154–157
  12. Kurzen H, Petzoldt D, Hartschuh W, Jappe U. Cutaneous necrosis after subcutaneous injection of polyethylene-glycol-modified interferon alpha. Acta Derm Venereol. 2002;82:310–312
  13. Sheremata WA, Taylor JR, Elgart GW. Severe necrotizing cutaneous lesions complicating treatment with interferon beta-1b. N Engl J Med. 1995;332:1584

 Funding sources: None.Conflicts of interest: None identified.

PII: S0190-9622(05)00698-5

doi: 10.1016/j.jaad.2005.02.031

Journal of the American Academy of Dermatology
Volume 53, Issue 1 , Pages 62-66 , July 2005

Article Tools

* Image Usage & Resolution