Journal of the American Academy of Dermatology
Volume 57, Issue 2 , Pages 247-256 , August 2007

The effect of a high-protein, low glycemic–load diet versus a conventional, high glycemic–load diet on biochemical parameters associated with acne vulgaris: A randomized, investigator-masked, controlled trial

  • Robyn N. Smith, BAppSc (Hons)

      Affiliations

    • From the School of Applied Sciences, RMIT University, Melbourne
    • Corresponding Author InformationReprint requests: Robyn Smith, BAppSc (Hons), School of Applied Sciences, RMIT University, GPO Box 2476V, Melbourne, Victoria, Australia, 3001.
    • ,
  • Neil J. Mann, BSc (Hons), BAppSc, PhD

      Affiliations

    • From the School of Applied Sciences, RMIT University, Melbourne
    • ,
  • Anna Braue, MBBS, MMed

      Affiliations

    • Department of Dermatology, Royal Melbourne Hospital, Parkville
    • ,
  • Henna Mäkeläinen, BAppSc

      Affiliations

    • Department of Biochemistry and Food Chemistry, Turku University
    • ,
  • George A. Varigos, MBBS, FACD, PhD

      Affiliations

    • Department of Dermatology, Royal Melbourne Hospital, Parkville
    • Department of Dermatology, Royal Children's Hospital, Parkville

,Accepted 9 January 2007.

References 

  1. Deplewski D, Rosenfield R. Role of hormones in pilosebaceous unit development. Endocr Rev. 2000;21:363–392
  2. Shaw J. Acne: the effect of hormones on pathogenesis and management. Am J Clin Dermatol. 2002;3:571–578
  3. Levell M, Cawood M, Burke B, Cunliffe W. Acne is not associated with abnormal plasma androgens. Br J Dermatol. 1989;120:649–654
  4. Slayden S, Moran C, Sams W, Boots L, Azziz R. Hyperandrogenemia in patients presenting with acne. Fertil Steril. 2001;75:889–892
  5. Lawrence D. Elevated free testosterone concentration in men and women with acne vulgaris. Clin Exp Dermatol. 1986;11:263–273
  6. Odlind V, Carlström K, Michaëlsson G, Vahlqvist A, Victor A, Mellbin T. Plasma androgenic activity in women with acne vulgaris and in healthy girls before, during and after puberty. Clin Endocrinol. 1982;16:243–249
  7. Lucky A, McGuire J, Rosenfield R, Lucky P, Rich B. Plasma androgens in women with acne vulgaris. J Invest Dermatol. 1983;81:70–74
  8. Cappel M, Mauger D, Thiboutot D. Correlation between serum levels of insulin-like growth factor 1, dehydroepidandrosterone sulfate, and dihydrotestosterone and acne lesion counts in adult women. Arch Dermatol. 2005;141:333–338
  9. Deplewski D, Rosenfield R. Growth hormone and insulin-like growth factors have different effects on sebaceous cell growth and differentiation. Endocrinology. 1999;140:4089–4094
  10. Aizawa H, Niimura M. Elevated serum insulin-like growth factor-I (IGF-I) levels in women with postadolescent acne. J Dermatol. 1995;22:249–252
  11. Franks S. Polycystic ovary syndrome. N Engl J Med. 2003;13:853–861
  12. Dunaif A, Segal K, Shelley D, Green G, Dorbrjansky A. Profound peripheral insulin resistance, independent of obesity in polycystic ovary syndrome. Diabetes. 1989;38:1165–1174
  13. Willis D, Mason H, Gilling-Smith C, Franks S. Modulation by insulin of follicle stimulating and luteinizing hormone action in human granulosa cells of normal and polycystic ovaries. J Clin Endocrinol Metab. 1996;81:302–309
  14. Kristiansen S, Endoh A, Casson P, Buster J, Hornsby P. Induction of steroidogenic enzyme genes by insulin and IGF-I in cultured adult human adrenocortical cells. Steroids. 1997;62:258–265
  15. Singh A, Hamilton-Fairley D, Koistinen R, Seppala M, James V, Franks S, et al. Effect of insulin-like growth factor-type I (IGF-I) and insulin on the secretion of sex hormone binding globulin and IGF-I binding protein (IBP-I) by human hepatoma cells. J Endocrinol. 1990;124:R1–R3
  16. Powell D, Suwanichkul A, Cubbage M, DePaolis L, Snuggs M, Lee P. Insulin inhibits transcription of the human gene for insulin-like growth factor-binding protein-1. J Biol Chem. 1991;266:18868–18876
  17. Ciotta L, Calogero AE, Farina M, De Leo V, La Marca A, Cianci A. Clinical, endocrine and metabolic effects of acarbose, an α-glucosidase inhibitor; in PCOS patients with increased insulin response and normal glucose tolerance. Hum Reprod. 2001;16:2066–2072
  18. Kazerooni T, Dehghan-Kooshkghazi M. Effect of metformin therapy on hyperandrogenism in women with polycystic ovary syndrome. Gynecol Endocrinol. 2003;17:51–56
  19. Kolodziejczyk B, Duleba AJ, Spaczynski RZ, Pawelczyk L. Metformin therapy decreases hyperandrogenism and hyperinsulinemia in women with polycystic ovary syndrome. Fertil Steril. 2000;73:1149–1154
  20. Smith C, Dunger D, AJK W, Taylor A, Perry L, Gale E, et al. Relationship between insulin, insulin-like growth factor I, and dehydroepiandrosterone sulfate concentrations during childhood, puberty and adult life. J Clin Endocrinol Metab 1989;68:932-7.
  21. Caprio S, Plewe G, Diamond M, Simonson D, Boulware S, Sherwin R, et al. Increased insulin secretion in puberty: a compensatory response to reductions in insulin sensitivity. J Pediatr. 1989;114:963–967
  22. Holly J, Smith C, Dunger D, Howell R, Chard T, Perry L, et al. Relationship between the pubertal fall in sex hormone binding globulin and insulin-like growth factor binding protein-I: a synchronized approach to pubertal development?. Clin Endocrinol. 1989;31:277–284
  23. Rolland-Cachera M. Body composition during adolescence: methods, limitations and determinants. Horm Res. 1993;39(Suppl):25–40
  24. Willett W, Manson J, Liu S. Glycemic index, glycemic load and risk of type 2 diabetes. Am J Clin Nutr. 2002;76(Suppl):274S–280S
  25. Jenkins D, Kendall C, Augustin L, Franceschi S, Hamidi M, Marchie A, et al. Glycemic index: overview of implications in healthy and disease. Am J Clin Nutr. 2002;76(Suppl):266S–273S
  26. Carnethon MR, Loria CM, Hill JO, Sidney S, Savage PJ, Liu K. Risk factors for the metabolic syndrome: the coronary artery risk development in young adults (CARDIA) study, 1985-2001. Diabetes Care. 2004;27:2707–2715
  27. McKeown N, Meigs J, Liu S, Saltzman E, Wilson P, Jacques P. Carbohydrate nutrition, insulin resistance and the prevalence of the metabolic syndrome in the Framingham offspring cohort. Diabetes Care. 2004;27:538–546
  28. Brand-Miller J, Thomas M, Swan V, Ahmad Z, Petocz P, Colagiuri S. Physiological validation of the concept of glycemic load in lean young adults. J Nutr. 2003;133:2695–2696
  29. Cordain L, Lindeberg S, Hurtado M, Hill K, Eaton B, Brand-Miller B. Acne vulgaris–a disease of Western civilization. Arch Dermatol. 2002;138:1584–1590
  30. Burke B, Cunliffe W. The assessment of acne vulgaris–the Leeds technique. Br J Dermatol. 1984;111:83–92
  31. Matthews D, Hosker J, Rudenski A, Naylor B, Treacher D, Turner R. Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologica. 1985;28:412–419
  32. Baxter R, Martin J. Radioimmunoassay of growth hormone-dependent insulin-like growth factor binding protein in human plasma. J Clin Invest. 1986;78:1504–1512
  33. Baxter R, Martin J, Wood M. Two immunoreactive binding proteins for insulin-like growth factors in human amniotic fluid: relationship to fetal maturity. J Clin Endocrinol Metab. 1987;65:423–431
  34. Friedewald W, Levy R, Fredrickson D. Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. Clin Chem. 1972;18:499–502
  35. Frost G, Keogh B, Smith D, Akinsanya K, Leeds A. The effect of low-glycemic carbohydrate on insulin and glucose response in vivo and in vitro in patients with coronary heat disease. Metabolism. 1996;45:669–672
  36. Hannah J, Howard B. Dietary fats, insulin resistance and diabetes. J Cardiovasc Risk. 1994;1:31–37
  37. Aizawa H, Niimura M. Mild insulin resistance during oral glucose tolerance test (OGTT) in women with acne. J Dermatol. 1996;23:526–529
  38. Bebakar W, Honour J, Foster D, Liu Y, Jacobs H. Regulation of testicular function by insulin and transforming growth factor-beta. Steroids. 1990;55:266–270
  39. Draelos Z. The effect of a daily facial cleanser for normal to oily skin on the skin barrier of subjects with acne. Cutis. 2006;78(Suppl):34–40
  40. Marynick S, Chakmajian Z, McCaffree D, Herdon J. Androgen excess in cystic acne. N Engl J Med. 1983;308:981–986
  41. Schiavone F, Rietschel R, Sgoutas D, Harris R. Elevated free testosterone levels in women with acne. J Invest Dermatol. 1983;81:70–74
  42. Cibula D, Hill M, Vohradnikova O, Kuzel D, Fanta M, Zivny J. The role of androgens in determining acne severity in adult women. Br J Dermatol. 2000;143:399–404
  43. Attia N, Tamborlane W, Heptulla R, Maggs D, Grozman A, Sherwin R, et al. The metabolic syndrome and insulin-like growth factor I regulation in adolescent obesity. J Clin Endocrinol Metab. 1998;83:1467–1471
  44. Kiddy D, Hamilton-Fairley D, Seppala M, Koistinen R, James V, Reed M, et al. Diet-induced changes in sex hormone binding globulin and free testosterone in women with normal or polycystic ovaries: correlation with serum insulin and insulin-like growth factor-I. Clin Endocrinol. 1989;31:757–763
  45. Guzick D, Wing R, Smith D, Berga S, Winters S. Endocrine consequences of weight loss in obese, hyperandrogenic, anovulatory women. Fertil Steril. 1994;61:598–604
  46. Prentice R, Thompson D, Clifford C, Gorbach S, Goldin B, Byar D. Dietary fat reduction and plasma estradiol concentration in healthy postmenopausal women: the women's health trial study group. J Natl Cancer Inst. 1990;82:129–134
  47. Rose D, Chlebowski R, Connolly J, Hones L, Wynder E. Effects of tamoxifen adjuvant therapy and a low-fat diet on serum binding proteins and estradiol bioavailability in postmenopausal breast cancer patients. Cancer Res. 1992;52:5386–5390
  48. Bourne S, Jacobs A. Observations on acne, seborrhoea, and obesity. Br Med J. 1956;1:1268–1270
  49. Daly M. Sugars, insulin sensitivity, and the postprandial state. Am J Clin Nutr. 2003;78(Suppl):865S–872S

 The study was supported by a research grant from Meat and Livestock Australia.Disclosure: This study was the responsibility of the investigators. Meat and Livestock Australia had no role in data collection, data analysis, data interpretation, or submission for publication. Ms Smith receives a postgraduate scholarship from MINTRAC (National Meat Industry Training Council of Australia). Authors Mann, Braue, Mäkeläinen, and Varigos had no conflicts of interest to disclose.Presented at the 15th Congress of the European Academy of Dermatology and Venereology Meeting in Rhodes, October 5, 2006, and at the Nutrition Society of Australia Meeting in Melbourne, December 2, 2005.

PII: S0190-9622(07)00414-8

doi: 10.1016/j.jaad.2007.01.046

Journal of the American Academy of Dermatology
Volume 57, Issue 2 , Pages 247-256 , August 2007

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