Journal of the American Academy of Dermatology
Volume 57, Issue 4 , Pages 588-593 , October 2007

Ultraviolet-B radiation increases serum 25-hydroxyvitamin D levels: The effect of UVB dose and skin color

  • Laura A.G. Armas, MD

      Affiliations

    • Creighton University Medical Center, Omaha, Nebraska
    • Corresponding Author InformationCorrespondence to: Laura A. G. Armas, MD, Creighton University Medical Center, 601 North 30th St, Suite 4820, Omaha, NE 68131.
    • ,
  • Susan Dowell, RN, PhD

      Affiliations

    • Creighton University Medical Center, Omaha, Nebraska
    • ,
  • Mohammed Akhter, PhD

      Affiliations

    • Creighton University Medical Center, Omaha, Nebraska
    • ,
  • Sowjanya Duthuluru, MD

      Affiliations

    • Creighton University Medical Center, Omaha, Nebraska
    • ,
  • Christopher Huerter, MD

      Affiliations

    • Creighton University Medical Center, Omaha, Nebraska
    • ,
  • Bruce W. Hollis, PhD

      Affiliations

    • Medical University of South Carolina, Charleston, South Carolina
    • ,
  • Richard Lund, MD

      Affiliations

    • Creighton University Medical Center, Omaha, Nebraska
    • ,
  • Robert P. Heaney, MD

      Affiliations

    • Creighton University Medical Center, Omaha, Nebraska

,Accepted 6 March 2007.

References 

  1. Heaney RP, Davies KM, Chen TC, Holick MF, Barger-Lux MJ. Human serum 25-hydroxy cholecalciferol response to extended oral dosing with cholecalciferol. Am J Clin Nutr. 2003;77:204–210
  2. Glerup H, Mikkelsen K, Poulsen L, Hass E, Overbeck S, Thomsen J, et al. Commonly recommended daily intake of vitamin D is not sufficient if sunlight exposure is limited. J Intern Med. 2000;247:260–268
  3. Webb AR. Who, what, where and when–influences on cutaneous vitamin D synthesis. Prog Biophys Mol Biol. 2006;92:17–25
  4. Haney EM, Stadler D, Bliziotes MM. Vitamin D insufficiency in internal medicine residents. Calcif Tissue Int. 2005;76:11–16
  5. Armas LAG, Hollis BW, Heaney RP. Vitamin D2 is much less effective than vitamin D3. J Clin Endocrinol Metab. 2004;89:5387–5391
  6. Holick MF. Sunlight “D”ilemma: risk of skin cancer or bone disease and muscle weakness. Lancet. 2001;357:4–6
  7. Holick MF. Vitamin D: a millennium perspective. J Cell Biochem. 2003;88:296–307
  8. Vieth R. Vitamin D supplementation, 25-hydroxyvitamin D concentrations, and safety. Am J Clin Nutr. 1999;69:842–856
  9. Matsuoka LY, Wortsman J, Haddad JG, Hollis BW. In vivo threshold for cutaneous synthesis of vitamin D3. J Lab Clin Med. 1989;114:301–305
  10. Chel VGM, Ooms ME, Popp-Snijders C, Pavel S, Schothorst AA, Meulemans CCE, et al. Ultraviolet irradiation corrects Vitamin D deficiency and suppresses secondary hyperparathyroidism in the elderly. J Bone Miner Res. 1998;13:1238–1242
  11. Koutkia P, Zhiren L, Chen TC, Holick M. Treatment of vitamin D deficiency due to Crohn's disease with tanning bed ultraviolet B radiation. Gastroenterology. 2001;121:1485–1488
  12. Leach EL, McClelland PB, Morgan P, Shelk J. Basic principles of photobiology and photochemistry for nurse phototherapists and phototechnicians. Dermatol Nurs. 1996;8:235–258
  13. Fitzpatrick TB. Soleil et peau. J Med Esthétique. 1975;2:33–34
  14. Barger-Lux MJ, Heaney RP. Effects of above average summer sun exposure on serum 25 hydroxyvitamin D and calcium absorption. J Clin Endocrinol Metab. 2002;87:4952–4956
  15. Hollis BW. Detection of vitamin D and its major metabolites. In:  Feldman D,  Glorieux FH,  Pike JW editor. Vitamin D. San Diego: Academic Press; 1997;p. 587–606
  16. Harris SS, Dawson-Hughes B. Seasonal changes in plasma 25-hydroxyvitamin D concentrations of young American black and white women. Am J Clin Nutr. 1998;67:1232–1236
  17. Nesby-O Dell S, Scanlon KS, Cogswell ME, Gillespie C, Hollis BW, Looker AC, et al. Hypovitaminosis D prevalence and determinants among African American and white women of reproductive age: third national health and nutrition examination survey, 1988-1994. Am J Clin Nutr. 2002;76:187–192
  18. Dawson-Hughes B, Harris SS, Dallal GE. Plasma calcidiol, season, and serum parathyroid hormone concentrations in healthy elderly men and women. Am J Clin Nutr. 1997;65:67–71
  19. Tangpricha V, Pearce EN, Chen TC, Holick MF. Vitamin D insufficiency among free-living healthy young adults. Am J Med. 2002;112:659–662
  20. Heaney RP, Dowell MS, Hale CA. Calcium absorption varies within the reference range for serum 25 hydroxyvitamin D. J Am Coll Nutr. 2003;22:142–146
  21. United States Department of Agriculture. UVB monitoring and research program. Available at http://www.nadp.nrel.colostate.edu/UV-B/home. Accessed January 15, 2007.
  22. Boran ED, Stern RS, Taylor CR. Correlating skin type and minimum erythema dose. Arch Dermatol. 1999;135:1278–1279
  23. MacLaughlin J, Holick MF. Aging decreases the capacity of human skin to produce vitamin D3. J Clin Invest. 1985;76:1536–1538

 Supported by Dialysis Clinics Inc, The Endocrine Fellows Foundation, and research funds of Creighton University.

 Disclosure: Dr Hollis is a consultant for Diasorin. Diasorin manufactures assays for 25-hydroxyvitamin D. Drs Armas, Dowell, Akhter, Duthuluru, Huerter, Lund, and Heaney have no conflicts of interest to declare.

 Reprints not available from the authors.

PII: S0190-9622(07)00500-2

doi: 10.1016/j.jaad.2007.03.004

Journal of the American Academy of Dermatology
Volume 57, Issue 4 , Pages 588-593 , October 2007

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