Journal of the American Academy of Dermatology
Volume 58, Issue 4 , Pages 579-584 , April 2008

Demographic and clinical properties of juvenile-onset Behçet's disease: A controlled multicenter study

  • Yelda Karincaoglu, MD

      Affiliations

    • Department of Dermatology and Venereology at Inonu University School of Medicine, Malatya, Turkey
    • Corresponding Author InformationReprint requests: Yelda Karincaoglu, MD, İnönü Üniversitesi, Tıp Fakültesi, Dermatoloji AD, 44315 Malatya, Turkey.
    • ,
  • Murat Borlu, MD

      Affiliations

    • Department of Dermatology and Venereology, Erciyes University, School of Medicine, Kayseri, Turkey
    • ,
  • Semra Cikman Toker, MD

      Affiliations

    • Department of Dermatology and Venereology, Uludag University, School of Medicine, Bursa, Turkey
    • ,
  • Ayse Akman, MD

      Affiliations

    • Department of Dermatology and Venereology, Akdeniz University, School of Medicine, Antalya, Turkey
    • ,
  • Meltem Onder, MD

      Affiliations

    • Department of Dermatology and Venereology, Gazi University, School of Medicine, Ankara, Turkey
    • ,
  • Suhan Gunasti, MD

      Affiliations

    • Department of Dermatology and Venereology, Cukurova University, School of Medicine, Adana, Turkey
    • ,
  • Aysegul Usta, MD

      Affiliations

    • Department of Dermatology and Venereology, Mersin University, School of Medicine, Mersin, Turkey
    • ,
  • Basak Kandi, MD

      Affiliations

    • Department of Dermatology and Venereology, Firat University, School of Medicine, Elazig, Turkey
    • ,
  • Cicek Durusoy, MD

      Affiliations

    • Department of Dermatology and Venereology, Baskent University Faculty of Medicine, Alanya Hospital, Alanya, Turkey
    • ,
  • Muammer Seyhan, MD

      Affiliations

    • Department of Dermatology and Venereology at Inonu University School of Medicine, Malatya, Turkey
    • ,
  • Serap Utas, MD

      Affiliations

    • Department of Dermatology and Venereology, Erciyes University, School of Medicine, Kayseri, Turkey
    • ,
  • Hayriye Saricaoglu, MD

      Affiliations

    • Department of Dermatology and Venereology, Uludag University, School of Medicine, Bursa, Turkey
    • ,
  • Muge Guler Ozden, MD

      Affiliations

    • Department of Dermatology and Venereology, Gazi University, School of Medicine, Ankara, Turkey
    • ,
  • Soner Uzun, MD

      Affiliations

    • Department of Dermatology and Venereology, Cukurova University, School of Medicine, Adana, Turkey
    • ,
  • Umit Tursen, MD

      Affiliations

    • Department of Dermatology and Venereology, Mersin University, School of Medicine, Mersin, Turkey
    • ,
  • Demet Cicek, MD

      Affiliations

    • Department of Dermatology and Venereology, Firat University, School of Medicine, Elazig, Turkey
    • ,
  • Levent Donmez, MD

      Affiliations

    • Department of Public Health, Akdeniz University School of Medicine, Antalya, Turkey
    • ,
  • Erkan Alpsoy, MD

      Affiliations

    • Department of Dermatology and Venereology, Akdeniz University, School of Medicine, Antalya, Turkey

,Accepted 16 October 2007.

References 

  1. Behçet H. Uber rezideivierende, aphtose, durch ein virus veursachte Geschure am Mund, Am Auge und an den Genitalien. Dermatol Wachenschr. 1937;105:1152–1157
  2. Direskeneli H. Behçet's disease: infectious etiology, new autoantigens, and HLA-B51. Ann Rheum Dis. 2001;60:996–1002
  3. Yazici H, Fresko I, Yurdakul S. Behcet's syndrome: disease manifestations, management, and advances in treatment. Nat Clin Pract Rheumatol. 2007;3:148–155
  4. Evereklioglu C. Current concepts in the etiology and treatment of Behçet disease. Surv Ophthalmol. 2005;50:297–350
  5. Gurler A, Boyvat A, Tursen U. Clinical manifestations of Behcet's disease: an analysis of 2147 patients. Yonsei Med J. 1997;38:423–427
  6. Saricaoglu H, Karadogan SK, Bayazit N, Yucel A, Dilek K, Tunali S. Clinical features of late-onset Behcet's disease: report of nine cases. Int J Dermatol. 2006;45:1284–1287
  7. Krause I, Uziel Y, Guedj D, Mukamel M, Harel L, Molad Y, et al. Childhood Behcet's disease: clinical features and comparison with adult-onset disease. Rheumatology (Oxford). 1999;38:457–462
  8. Eldem B, Onur C, Ozen S. Clinical features of pediatric Behcet's disease. J Pediatr Ophthalmol Strabismus. 1998;35:159–161
  9. Treudler R, Orfanos CE, Zouboulis CC. Twenty-eight cases of juvenile-onset Adamantiades-Behçet disease in Germany. Dermatology. 1999;199:15–19
  10. Sarica R, Azizlerli G, Kose A, Disci R, Ovul C, Kural Z. Juvenile Behcet's disease among 1784 Turkish Behcet's patients. Int J Dermatol. 1996;35:109–111
  11. Borlu M, Uksal U, Ferahbas A, Evereklioglu C. Clinical features of Behcet's disease in children. Int J Dermatol. 2006;45:713–716
  12. Tugal-Tutkun I, Urgancioglu M. Childhood-onset uveitis in Behcet disease: a descriptive study of 36 cases. Am J Ophthalmol. 2003;136:1114–1119
  13. International Study Group for Behcet's Disease . Criteria for diagnosis of Behcet's disease. Lancet. 1990;335:1078–1080
  14. Mundy TM, Miller JJ. Behcet's disease presenting as chronic aphthous stomatitis in a child. Pediatrics. 1978;62:205–208
  15. Kari JA, Shah V, Dillon MJ. Behçet's disease in UK children: clinical features and treatment including thalidomide. Rheumatology. 2001;40:933–938
  16. Allali F, Benomar A, Karim A, Lazrak N, Mohcine Z, El Yahyaoui M, et al. Behcet's disease in Moroccan children: a report of 12 cases. Scand J Rheumatol. 2004;33:362–363
  17. Kone-Paut I, Yurdakul S, Bahabri SA, Shafae N, Ozen S, Ozdogan H, et al. Clinical features of Behçet's disease in children: an international collaborative study of 86 cases. J Pediatr. 1998;132:721–725
  18. Kone-Paut I, Gorchakoff-Molinas A, Weschler B, Touitou I. Pediatric Behcet's disease in France. Ann Rheum Dis. 2002;61:655–656
  19. Bahabri SA, al-Mazyed A, al-Balaa S, el-Ramahi L, al-Dalaan A. Juvenile Behcet's disease in Arab children. Clin Exp Rheumatol. 1996;14:331–335
  20. Uziel Y, Brik R, Padeh S, Barash J, Mukamel M, Harel L, et al. Juvenile Behçet's disease in Israel: the pediatric rheumatology study group of Israel. Clin Exp Rheumatol. 1998;16:502–505
  21. Pivetti-Pezzi P, Accorinti M, Abdulaziz MA, La Cava M, Torella M, Riso D. Behçet's disease in children. Jpn J Ophthalmol. 1995;39:309–314
  22. Fresko I, Soy M, Hamuryudan V, Yurdakul S, Yavuz S, Tumer Z, et al. Genetic anticipation in Behcet's syndrome. Ann Rheum Dis. 1998;57:45–48
  23. Alpsoy E, Donmez L, Onder M, Gunasti S, Usta A, Karincaoglu Y, et al. Clinical features and natural course of Behçet's disease in 661 cases: a multicenter study. Br J Dermatol. 2007;157:901–906
  24. Akbaylar H. Behcet's disease with multisystem involvement: Entero-Behcet. Turkiye Klinikleri U Int Med Sci. 2007;3:20–32

 Funding sources: None.

 Conflicts of interest: None declared.

 Presented as free communication at the XII International Conference on Behçet's Disease, in Lisbon, Portugal, on September 20-23, 2006.

PII: S0190-9622(07)02022-1

doi: 10.1016/j.jaad.2007.10.452

Journal of the American Academy of Dermatology
Volume 58, Issue 4 , Pages 579-584 , April 2008

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