Journal of the American Academy of Dermatology
Volume 58, Issue 4 , Pages 592-595 , April 2008

Total skin electron beam therapy may be associated with improvement of peripheral blood disease in Sézary syndrome

  • Camille E. Introcaso, MD

      Affiliations

    • Department of Dermatology, University of Pennsylvania, Philadelphia, Pennsylvania
    • ,
  • Bizhan Micaily, MD, FACR

      Affiliations

    • Department of Radiation Oncology, Temple University School of Medicine, Philadelphia, Pennsylvania
    • ,
  • Stephen K. Richardson, MD

      Affiliations

    • Department of Dermatology, University of Pennsylvania, Philadelphia, Pennsylvania
    • ,
  • Jacqueline M. Junkins-Hopkins, MD

      Affiliations

    • Department of Dermatology, University of Pennsylvania, Philadelphia, Pennsylvania
    • ,
  • Jessica S. Yoon, MD

      Affiliations

    • Department of Dermatology, University of Pennsylvania, Philadelphia, Pennsylvania
    • ,
  • Ellen J. Kim, MD

      Affiliations

    • Department of Dermatology, University of Pennsylvania, Philadelphia, Pennsylvania
    • ,
  • Carmela C. Vittorio, MD

      Affiliations

    • Department of Dermatology, University of Pennsylvania, Philadelphia, Pennsylvania
    • ,
  • Alain H. Rook, MD

      Affiliations

    • Department of Dermatology, University of Pennsylvania, Philadelphia, Pennsylvania
    • Corresponding Author InformationReprint requests: Alain H. Rook, MD, Department of Dermatology, Hospital of the University of Pennsylvania, 2 Maloney Bldg, 3400 Spruce St, Philadelphia, PA 19104.

,Accepted 19 December 2007.

References 

  1. Kim E, Hess S, Richardson S, Newton S, Showe LC, Benoit BM, et al. Immunopathogenesis and therapy of cutaneous T-cell lymphoma. J Clin Invest. 2005;115:798–812
  2. Kim Y, Liu H, Mraz-Gernhard S, Varghese A, Hoppe RT. Long-term outcome of 525 patients with mycosis fungoides and Sézary syndrome: clinical prognostic factors and risk for disease progression. Arch Dermatol. 2003;139:857–866
  3. Richardon S, Lin J, Vittorio C, Kim EJ, Yoon JS, Junkins-Hopkins JM, et al. High clinical response rate with multimodality immunomodulatory therapy for Sézary syndrome. Clin Lymphoma Myeloma. 2006;7:226–232
  4. Jones GW, Kacinski BM, Wilson LD, Willemze R, Spittle M, Hohenberg G, et al. Total skin electron radiation in the management of mycosis fungoides: consensus of the European Organization for Research and Treatment of Cancer cutaneous lymphoma project group. J Am Acad Dermatol. 2002;47:364–370
  5. Wilson LD, Jones GW, Kim D, Rosenthal D, Christensen IR, Edelson RL, et al. Experience with total skin electron beam therapy in combination with extracorporeal photopheresis in the management of patients with erythrodermic (T4) mycosis fungoides. J Am Acad Dermatol. 2000;43:54–60
  6. Jones GW, Rosenthal D, Wilson LD. Total skin electron radiation for patients with erythrodermic cutaneous T-cell lymphoma (mycosis fungoides and the Sézary syndrome). Cancer. 1999;85:1985–1995
  7. Willemze R, Jaffe ES, Burg G, Cerroni L, Berti B, Swerlow SH, et al. WHO-EORTC classification for cutaneous lymphomas. Blood. 2005;105:3768–3785
  8. Olsen E, Vonderheid E, Pimpinelli N, Willemze R, Kim Y, Knobler R, et al. Revised staging and classification of MF/SS. Blood. 2007;110:1713–1722
  9. In:  Perez CA,  Brady LW editor. Principles and practices of radiation oncology. Philadelphia: Lippincott-Raven; 1998;
  10. Oyekunle A, Kroger N, Zabelina T, Ayuk F, Schieder H, Renges H, et al. Allogeneic stem-cell transplantation in patients with refractory acute leukemia: a long-term follow-up. Bone Marrow Transplant. 2006;37:45–50
  11. Molina A, Zain J, Arber D, Angelopolou M, O'Donnell M, Murata-Collins J, et al. Durable clinical, cytogenetic, and molecular remissions after allogeneic hematopoietic cell transplantation for refractory Sézary syndrome and mycosis fungoides. J Clin Oncol. 2005;23:6163–6171
  12. Yoo E, Cassin M, Lessin S, Rook AH. Complete molecular remission during biologic response modifier therapy for Sézary syndrome is associated with enhanced helper T type 1 cytokine production and natural killer cell activity. J Am Acad Dermatol. 2001;45:208–216

 Funding sources: None.

 Conflicts of interest: None declared.

PII: S0190-9622(07)02535-2

doi: 10.1016/j.jaad.2007.12.016

Journal of the American Academy of Dermatology
Volume 58, Issue 4 , Pages 592-595 , April 2008

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