Journal of the American Academy of Dermatology
Volume 58, Issue 5 , Pages 826-850, May 2008

Guidelines of care for the management of psoriasis and psoriatic arthritis:

Section 1. Overview of psoriasis and guidelines of care for the treatment of psoriasis with biologics

  • Alan Menter, MD, Chair

      Affiliations

    • Baylor University Medical Center, Dallas, Texas
    • ,
  • Alice Gottlieb, MD, PhD

      Affiliations

    • Department of Dermatology, Tufts-New England Medical Center, Tufts University School of Medicine, Boston, Massachusetts
    • ,
  • Steven R. Feldman, MD, PhD

      Affiliations

    • Department of Dermatology, Wake Forest University School of Medicine, Winston-Salem, North Carolina
    • ,
  • Abby S. Van Voorhees, MD

      Affiliations

    • Department of Dermatology, University of Pennsylvania, Philadelphia, Pennsylvania
    • ,
  • Craig L. Leonardi, MD

      Affiliations

    • Saint Louis University, Saint Louis, Missouri
    • ,
  • Kenneth B. Gordon, MD

      Affiliations

    • Division of Dermatology, Evanston Northwestern Healthcare and Department of Dermatology, Northwestern University, Fienberg School of Medicine, Chicago, Illinois
    • ,
  • Mark Lebwohl, MD

      Affiliations

    • Department of Dermatology, Mount Sinai School of Medicine, New York, New York
    • ,
  • John Y.M. Koo, MD

      Affiliations

    • Department of Dermatology, University of California–San Francisco, San Francisco, California
    • ,
  • Craig A. Elmets, MD

      Affiliations

    • Department of Dermatology, University of Alabama at Birmingham, Birmingham, Alabama
    • ,
  • Neil J. Korman, MD, PhD

      Affiliations

    • Murdough Family Center For Psoriasis, Department of Dermatology, University Hospitals Case Medical Center, Cleveland, Ohio
    • ,
  • Karl R. Beutner, MD, PhD

      Affiliations

    • Anacor Pharmaceuticals Inc, Palo Alto, California
    • ,
  • Reva Bhushan, PhD

      Affiliations

    • American Academy of Dermatology, Schaumburg, Illinois
    • Corresponding Author InformationReprint requests: Reva Bhushan, PhD, 930 E Woodfield Rd, Schaumburg, IL 60173.

Psoriasis is a common, chronic, inflammatory, multisystem disease with predominantly skin and joint manifestations affecting approximately 2% of the population. In this first of 5 sections of the guidelines of care for psoriasis, we discuss the classification of psoriasis; associated comorbidities including autoimmune diseases, cardiovascular risk, psychiatric/psychologic issues, and cancer risk; along with assessment tools for skin disease and quality-of-life issues. Finally, we will discuss the safety and efficacy of the biologic treatments used to treat patients with psoriasis.

Abbreviations used: AAD, American Academy of Dermatology, BMI, body mass index, BSA, body surface area, CHF, congestive heart failure, CyA, cyclosporine, FDA, Food and Drug Administration, IL, interleukin, LFA, lymphocyte function associated antigen, MS, multiple sclerosis, NB, narrowband, PASI, Psoriasis Area and Severity Index, PASI-75, 75% improvement in the Psoriasis Area and Severity Index score, PGA, Physicians Global Assessment, PUVA, psoralen plus ultraviolet A, QOL, quality of life, TB, tuberculosis, TNF, tumor necrosis factor, UV, ultraviolet

 

 Funding sources: None.

 The authors' conflict of interest/disclosure statements appear at the end of the article.

PII: S0190-9622(08)00273-9

doi:10.1016/j.jaad.2008.02.039

Journal of the American Academy of Dermatology
Volume 58, Issue 5 , Pages 826-850, May 2008