Journal of the American Academy of Dermatology
Volume 60, Issue 2 , Pages 236-247 , February 2009

Spitz nevi: In vivo confocal microscopic features, dermatoscopic aspects, histopathologic correlates, and diagnostic significance

  • Giovanni Pellacani, MD

      Affiliations

    • Department of Dermatology, University of Modena and Reggio Emilia, Modena, Italy
    • Corresponding Author InformationReprint requests: Giovanni Pellacani, MD, Department of Dermatology, University of Modena and Reggio Emilia, Via del Pozzo 71, 41100 Modena, Italy.
    • ,
  • Caterina Longo, MD

      Affiliations

    • Department of Dermatology, University of Modena and Reggio Emilia, Modena, Italy
    • ,
  • Gerardo Ferrara, MD

      Affiliations

    • Department of Pathology, Pathologic Anatomy Unit, Gaetano Rummo General Hospital, Benevento, Italy
    • ,
  • Anna Maria Cesinaro, MD

      Affiliations

    • Department of Pathology, University of Modena and Reggio Emilia, Modena, Italy
    • ,
  • Sara Bassoli, MD

      Affiliations

    • Department of Dermatology, University of Modena and Reggio Emilia, Modena, Italy
    • ,
  • Pascale Guitera, MD

      Affiliations

    • Sydney Melanoma Diagnostic Centre, Sydney Cancer Centre and Dermatology Department, Royal Prince Alfred Hospital, Faculty of Medicine, University of Sydney, Sydney, Australia
    • ,
  • Scott W. Menzies, MB BS, PhD

      Affiliations

    • Sydney Melanoma Diagnostic Centre, Sydney Cancer Centre and Dermatology Department, Royal Prince Alfred Hospital, Faculty of Medicine, University of Sydney, Sydney, Australia
    • ,
  • Stefania Seidenari, MD

      Affiliations

    • Department of Dermatology, University of Modena and Reggio Emilia, Modena, Italy

,Accepted 14 July 2008.

References 

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  12. Stolz W, Braun-Falco O, Bilek P, Landthaler M, Cognetta AB. Pigmented spindle-cell nevus and Spitz nevus. In:  Stolz W,  Braun-Falco O,  Bilek P,  Landthaler M,  Cognetta AB editor. Color atlas of dermatoscopy. Oxford (United Kingdom): Blackwell Science Ltd; 1994;p. 66–70
  13. Argenziano G, Soyer HP, Ferrara G, Piccolo D, Hofmann-Wellenhof R, Peris K, et al. Superficial black network: an additional dermoscopic clue for the diagnosis of spindle and/or epithelioid cell nevus. Dermatology. 2001;203:333–335
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  19. González S, Gilaberte-Calzada Y, González-Rodríguez A, Torres A, Mihm MC. In vivo reflectance-mode confocal scanning laser microscopy in dermatology. Adv Dermatol. 2004;20:371–387
  20. Pellacani G, Guitera P, Longo C, Avramidis M, Seidenari S, Menzies S. The impact of in vivo reflectance confocal microscopy for the diagnostic accuracy of melanoma and equivocal melanocytic lesions. J Invest Dermatol. 2007;127:2759–2765
  21. Pellacani G, Cesinaro AM, Grana C, Seidenari S. In vivo confocal scanning laser microscopy of pigmented Spitz nevi: comparison of in vivo confocal images with dermoscopy and routine histopathology. J Am Acad Dermatol. 2004;51:371–376
  22. Rajadhyaksha M, Gonzalez S, Zavislan JM, Anderson RR, Webb RH. In vivo confocal scanning laser microscopy of human skin II: advances in instrumentation and comparison with histology. J Invest Dermatol. 1999;113:293–303
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  24. Scope A, Benvenuto-Andrade C, Agero AL, Malvehy J, Puig S, Rajadhyaksha M, et al. In vivo reflectance confocal microscopy imaging of melanocytic skin lesions: consensus terminology glossary and illustrative images. J Am Acad Dermatol. 2007;57:644–658
  25. Pellacani G, Cesinaro AM, Seidenari S. Reflectance-mode confocal microscopy of pigmented skin lesions-improvement in melanoma diagnostic specificity. J Am Acad Dermatol. 2005;53:979–985
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  27. Urso C. Melanocytic lesions, Spitz tumors, and Don Ferrante's logic. Am J Dermatopathol. 2007;29:491–494
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  32. Pellacani G, Bassoli S, Longo C, Cesinaro AM, Seidenari S. Diving into the blue: in vivo microscopic characterization of the dermoscopic blue hue. J Am Acad Dermatol. 2007;57:96–104
  33. Pellacani G, Longo C, Malvehy J, Puig S, Carrera C, Segura S, et al. In vivo confocal microscopic and histopathologic correlations of dermoscopic features in 202 melanocytic lesions. Arch Dermatol. In press.

 Supported in part by a grant of the Fondazione Cassa di Risparmio di Modena.

 Conflicts of interest: None declared.

PII: S0190-9622(08)01083-9

doi: 10.1016/j.jaad.2008.07.061

Journal of the American Academy of Dermatology
Volume 60, Issue 2 , Pages 236-247 , February 2009

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