Journal of the American Academy of Dermatology
Volume 60, Issue 1 , Pages 77-84 , January 2009

Narrowband ultraviolet B and medium-dose ultraviolet A1 are equally effective in the treatment of moderate to severe atopic dermatitis

  • I.M. Leonie Majoie, MD

      Affiliations

    • Department of Dermatology and Allergology, University Medical Center Utrecht, The Netherlands
    • These authors contributed equally to this study.
    • ,
  • J. Marja Oldhoff, MD, PhD

      Affiliations

    • Department of Dermatology and Allergology, University Medical Center Utrecht, The Netherlands
    • Corresponding Author InformationReprint requests: J. Marja Oldhoff, MD, PhD, University Medical Center Utrecht, Heidelberglaan 100, Department of Dermatology, G02.124, 3508 GA Utrecht, the Netherlands.
    • These authors contributed equally to this study.
    • ,
  • Huib van Weelden, MSc

      Affiliations

    • Department of Dermatology and Allergology, University Medical Center Utrecht, The Netherlands
    • ,
  • Marloes Laaper-Ertmann

      Affiliations

    • Department of Dermatology and Allergology, University Medical Center Utrecht, The Netherlands
    • ,
  • Mente T. Bousema, MD

      Affiliations

    • Department of Dermatology, Meander Medical Center, Amersfoort, The Netherlands
    • ,
  • Vigfus Sigurdsson, MD, PhD

      Affiliations

    • Department of Dermatology and Allergology, University Medical Center Utrecht, The Netherlands
    • ,
  • Edward F. Knol, PhD

      Affiliations

    • Department of Dermatology and Allergology, University Medical Center Utrecht, The Netherlands
    • ,
  • Carla A.F. Bruijnzeel-Koomen, MD, PhD

      Affiliations

    • Department of Dermatology and Allergology, University Medical Center Utrecht, The Netherlands
    • ,
  • Marjolein S. de Bruin-Weller, MD, PhD

      Affiliations

    • Department of Dermatology and Allergology, University Medical Center Utrecht, The Netherlands

,Accepted 29 August 2008.

  • Image Result

    Trial flow chart. During the treatment period phototherapy was administered 3 times/wk; patients were randomly assigned to receive narrowband ultraviolet (UV) B to one side of the body and medium-dose

    Trial flow chart. During the treatment period phototherapy was administered 3 times/wk; patients were randomly assigned to receive narrowband ultraviolet (UV) B to one side of the body and medium-dose UVA1 to the other side. LSS, Leicester sign score; VAS, visual analog scale.

  • Image Result
    Clinical results. Mean reduction in Leicester sign score (LSS) (A) and visual analog scale (VAS) pruritus (B). No significant difference in favor of narrowband (NB) ultraviolet (UV) B. MD, Medium dose

    Clinical results. Mean reduction in Leicester sign score (LSS) (A) and visual analog scale (VAS) pruritus (B). No significant difference in favor of narrowband (NB) ultraviolet (UV) B. MD, Medium dose; X-axes, time in weeks; Y-axes, mean score. Vertical lines display SD.

  • Image Result
    Immunohistochemical results (n = 9). Cellular infiltrate before (t = 0) and after (t = 8) phototherapy in patients with atopic dermatitis. Treatment of one body side was with narrowband (NB) ultraviol

    Immunohistochemical results (n = 9). Cellular infiltrate before (t = 0) and after (t = 8) phototherapy in patients with atopic dermatitis. Treatment of one body side was with narrowband (NB) ultraviolet (UV) B and other body side with medium-dose (MD) UVA1. AA1, Mast cell; elastase, neutrophil; CD1a, dendritic cell; CD3, T cell; EG2, eosinophil; X-axes, time: 0 = lesional skin, 8 = after 8 weeks of phototherapy; Y-axes, cells/mm2. ∗Significantly different decrease in cells compared with t = 0. No significant differences were observed between NB UVB and MD UVA1 sides.

  • Image Result
    Immunohistochemical results of forkhead box protein P3 (n = 9). Cellular infiltrate before (t = 0) and after (t = 8) phototherapy in patients with atopic dermatitis. Treatment of one body side was wit

    Immunohistochemical results of forkhead box protein P3 (n = 9). Cellular infiltrate before (t = 0) and after (t = 8) phototherapy in patients with atopic dermatitis. Treatment of one body side was with narrowband (NB) ultraviolet (UV) B and other body side with medium-dose (MD) UVA1. CD3, T cell; FoxP3, positive T cell; X-axes, time: 0 = lesional skin, 8 = after 8 weeks of phototherapy; Y-axes, cells/mm2. ∗Significant decrease in cells compared with t = 0. No significant differences were observed between NB UVB and MD UVA1 sides.

 Funding sources: None.

 Conflicts of interest: None declared.

PII: S0190-9622(08)01213-9

doi: 10.1016/j.jaad.2008.08.048

Journal of the American Academy of Dermatology
Volume 60, Issue 1 , Pages 77-84 , January 2009

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