Journal of the American Academy of Dermatology
Volume 60, Issue 2 , Pages 212-217 , February 2009

Effect of sequential applications of topical tacrolimus and topical corticosteroids in the treatment of pediatric atopic dermatitis: An open-label pilot study

  • Yasuo Kubota, MD

      Affiliations

    • Department of Dermatology, Faculty of Medicine, Kagawa University, Kagawa, Japan
    • Corresponding Author InformationReprint requests: Yasuo Kubota, MD, Department of Dermatology, Faculty of Medicine, Kagawa University, 1750-1, Ikenobe, Miki-cho, Kita-gun, Kagawa, Japan 761-0793.
    • ,
  • Kozo Yoneda, MD

      Affiliations

    • Department of Dermatology, Faculty of Medicine, Kagawa University, Kagawa, Japan
    • ,
  • Kozo Nakai, MD

      Affiliations

    • Department of Dermatology, Faculty of Medicine, Kagawa University, Kagawa, Japan
    • ,
  • Junko Katsuura, MD

      Affiliations

    • Department of Dermatology, Faculty of Medicine, Kagawa University, Kagawa, Japan
    • ,
  • Tetsuya Moriue, MD

      Affiliations

    • Department of Dermatology, Faculty of Medicine, Kagawa University, Kagawa, Japan
    • ,
  • Yoshie Matsuoka, MD

      Affiliations

    • Department of Dermatology, Faculty of Medicine, Kagawa University, Kagawa, Japan
    • ,
  • Izumi Miyamoto, MD

      Affiliations

    • Department of Dermatology, Faculty of Medicine, Kagawa University, Kagawa, Japan
    • ,
  • Yukihiro Ohya, MD

      Affiliations

    • Division of Allergy, Department of Medical Specialties, National Center for Child Health and Development, Tokyo, Japan

,Accepted 23 September 2008.

References 

  1. Morgan M, McCreedy R, Simpson J, Hay RJ. Dermatology quality of life scales: a measure of the impact of skin diseases. Br J Dermatol. 1997;136:202–206
  2. Su JC, Kemp AS, Varigos GA, Nolan TM. Atopic eczema: its impact on the family and financial cost. Arch Dis Child. 1997;76:159–162
  3. Hanifin JM, Cooper KD, Ho VC, Kang S, Krafchik BR, Margolis DJ, et al. Guideline of care for atopic dermatitis: developed in accordance with the American Academy of Dermatology (AAD)/American Academy of Dermatology Association “administrative regulations for evidence-based clinical practice guideline”. J Am Acad Dermatol. 2004;50:391–404
  4. Sidbury R, Hanifin JM. Old, new, and emerging therapies for atopic dermatitis. Dermatol Clin. 2000;38:1–11
  5. Ruzicka T, Bieber T, Schopf E, Rubins A, Dobozy A, Bos JD, et al. A short-term trail of tacrolimus ointment for atopic dermatitis. N Engl J Med. 1998;337:816–821
  6. Caproni M, Torchia D, Antiga E, Terranova M, Volpi W, Del Bianco E, et al. The comparative effects of tacrolimus and hydrocortisone in adult atopic dermatitis: an immunohistochemical study. Br J Dermatol. 2007;156:312–319
  7. Norris DA. Mechanisms of action of topical therapies and the rationale for combination therapy. J Am Acad Dermatol. 2005;53(Suppl):S17–S25
  8. Torok HM, Maas-Irslinger R, Slayton RM. Clocortolone pivalate cream 0.1% used concomitantly with tacrolimus ointment 0.1% in atopic dermatitis. Cutis. 2003;72:161–166
  9. Sprangers MAG, Schwartz CE. Integrating response shift into health-related quality of life research: a theoretical model. Soc Sci Med. 1999;48:1507–1515
  10. Finlay AY. Quality of life assessments in dermatology. Semin Cutan Med Surg. 1998;17:291–296
  11. Hanifin JM, Rajka G. Diagnostic features of atopic dermatitis. Acta Derm Venereol Suppl (Stockh). 1980;92:44–47
  12. Rajka G, Langeland T. Grading of the severity of atopic dermatitis. Acta Derm Venereol Suppl (Stockh). 1989;144:13–14
  13. Ohya Y, Sasaki R, Matsumoto M, Riazi A, Lewis-Jones SM, Finlay A. Development of the Japanese version of the Children's Dermatology Life Quality Index (CDLQI). [abstract] Arerugi. 2002;51:265
  14. Schwartz CE, Sprangers MAG. Methodological approaches for assessing response shift in longitudinal quality of life research. Soc Sci Med. 1999;48:1531–1548
  15. Susan J, Tofte RN, Hanifin JM. Current management and therapy of atopic dermatitis. J Am Acad Dermatol. 2001;44(Suppl):S13–S16
  16. Drake L, Prendergast M, Maher R, Breneman D, Korman N, Satoi Y, et al. The impact of tacrolimus ointment on health-related quality of life of adult and pediatric patients with atopic dermatitis. J Am Acad Dermatol. 2001;44(Suppl):S65–S72
  17. Timmerman AA, Anteunis LJC, Meesters CMG. Response-shift bias and parent-reported quality of life in children with otitis media. Arch Otolaryngol Head Neck Surg. 2003;129:987–991

 Funding sources: None.

 Conflicts of interest: None declared.

PII: S0190-9622(08)01215-2

doi: 10.1016/j.jaad.2008.09.034

Journal of the American Academy of Dermatology
Volume 60, Issue 2 , Pages 212-217 , February 2009

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