Journal of the American Academy of Dermatology
Volume 60, Issue 5 , Pages 786-791 , May 2009

Medium-dose is more effective than low-dose ultraviolet A1 phototherapy for localized scleroderma as shown by 20-MHz ultrasound assessment

  • Paul-Gunther Sator, MD

      Affiliations

    • Division of Special and Environmental Dermatology, Department of Dermatology, Medical University of Vienna, Vienna, Austria
    • ,
  • Sonja Radakovic, MD

      Affiliations

    • Division of Special and Environmental Dermatology, Department of Dermatology, Medical University of Vienna, Vienna, Austria
    • ,
  • Karl Schulmeister, PhD

      Affiliations

    • Austrian Research Centers GesmbH, Seibersdorf, Austria
    • ,
  • Herbert Hönigsmann, MD

      Affiliations

    • Division of Special and Environmental Dermatology, Department of Dermatology, Medical University of Vienna, Vienna, Austria
    • ,
  • Adrian Tanew, MD

      Affiliations

    • Division of Special and Environmental Dermatology, Department of Dermatology, Medical University of Vienna, Vienna, Austria
    • Corresponding Author InformationReprint requests: Adrian Tanew, MD, Division of Special and Environmental Dermatology, Department of Dermatology, Medical University of Vienna, Währinger Gürtel 18-20, A-1090 Vienna, Austria.

,Accepted 7 December 2008.

References 

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  3. Rowell NR, Goodfield MJD. The connective tissue diseases. In:  Champion RH,  Burton JL,  Ebling FJG editor. Textbook of dermatology. Vol 3. Oxford: Blackwell Scientific Publications; 1992;p. 2225–2266
  4. Peterson LS, Nelson AM, Su WPD. Classification of morphea (localized scleroderma). Mayo Clin Proc. 1995;70:1068–1076
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  9. Kerscher M, Volkenandt M, Gruss C, Reuther T, von Kobyletzki G, Freitag M, et al. Low-dose UVA1 phototherapy for treatment of localized scleroderma. J Am Acad Dermatol. 1998;38:21–26
  10. Clements PJ, Lachenbruch PA, Ng SC, Simmons M, Sterz M, Furst DE. Skin score: a semiquantitative measure of cutaneous involvement that improves prediction of prognosis in systemic sclerosis. Arthritis Rheum. 1990;33:1256–1263
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  15. El-Mofty M, Zaher H, Bosseila M, Youssef R, Saad B. Low-dose broad-band UVA in morphea using a new method for evaluation. Photodermatol Photoimmunol Photomed. 2000;16:43–49
  16. Steger JW, Matthews JH. UVA therapy for scleroderma. J Am Acad Dermatol. 1999;40:787–788
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  18. Sator P-G, Schmidt JB, Hönigsmann H. Objective assessment of photoageing effects using high-frequency ultrasound in PUVA-treated psoriasis patients. Br J Dermatol. 2002;147:291–298
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  20. Scharfetter K, Wlaschek M, Hogg A, Bolsen K, Schothorst A, Goerz G, et al. UVA irradiation induces collagenase in human dermal fibroblasts in vitro and in vivo. Arch Dermatol Res. 1991;283:506–511
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  24. El-Mofty M, Mostafa W, El-Darouty M, Bosseila M, Nada H, Yousef R, et al. Different low doses of broad-band UVA in the treatment of morphea and systemic sclerosis: a clinico-pathologic study. Photodermatol Photoimmunol Photomed. 2004;20:148–156

 Funding sources: None.

 Conflicts of interest: None declared.

PII: S0190-9622(08)02496-1

doi: 10.1016/j.jaad.2008.12.013

Journal of the American Academy of Dermatology
Volume 60, Issue 5 , Pages 786-791 , May 2009

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