Journal of the American Academy of Dermatology
Volume 62, Issue 1 , Pages 136-138 , January 2010

Mibelli revisited: A case of type 2 segmental porokeratosis from 1893

  • Rudolf Happle, MD

      Affiliations

    • Corresponding Author InformationReprint requests: Rudolf Happle, MD, Deutschhaus-Str 9, 35033, Marburg, Germany.

References 

  1. Mibelli V. Contributo allo studio della ipercheratosi dei canali sudoriferi (porokeratosi). G It Mal Vener Pelle. 1893;28:313–355
  2. Mibelli V. An uncommon form of keratodermia: “porokeratosis”. In: Unna PG, Morris M, Leloir H, Duhring LA, eds. Internationaler Atlas seltener Hautkrankheiten. International Atlas of Rare Skin Diseases. Atlas international des maladies rares de la peau. Fascicle IX, edited on 28 October 1893, pp 5-10, plate XXVII. Hamburg: Voss; 1893.
  3. Allegra F. Vittorio Mibelli and the tale of « porokeratosis ». Am J Dermatopathol. 1986;8:169–172
  4. Schamroth JM, Zlotogorski A, Gilead L. Porokeratosis of Mibelli: overview and review of the literature. Acta Derm Venereol. 1997;77:207–213
  5. Happle R. Somatic recombination may explain linear porokeratosis associated with disseminated superficial actinic porokeratosis. Am J Med Genet. 1991;39:237
  6. Happle R. Dohi Memorial Lecture: New aspects of cutaneous mosaicism. J Dermatol. 2002;29:681–692
  7. Rech G, Arieti S, Iorizzo M, Tosti A. Vittorio Mibelli (1860-1910). In:  Löser C,  Plewig G editor. Pantheon der Dermatologie. Heidelberg: Springer Medizin Verlag; 2008;p. 688–693
  8. Chernosky ME, Freeman RG. Disseminated superficial actinic porokeratosis (DSAP). Arch Dermatol. 1967;96:611–624
  9. Mibelli V. Ueber einen Fall von Porokeratosis mit Localisation im Munde und an der Glans. Arch Dermatol Syph (Vienna). 1899;47:231–243
  10. Happle R. A rule concerning the segmental manifestation of autosomal dominant skin disorders: review of clinical examples providing evidence for dichotomous types of severity. Arch Dermatol. 1997;133:1505–1509
  11. Happle R. Loss of heterozygosity in human skin. J Am Acad Dermatol. 1999;41:143–161
  12. Happle R. Type 2 segmental acanthosis nigricans: a historical case explained by a new concept. Arch Dermatol. 2008;144:1637
  13. Poblete-Gutiérrez P, Wiederholt T, König A, Jugert FK, Marquardt Y, Rübben A, et al. Allelic loss underlies type 2 segmental Hailey-Hailey disease, providing molecular confirmation of a novel genetic concept. J Clin Invest. 2004;114:1467–1474
  14. Happle R. Type 2 segmental Cowden disease vs. Proteus syndrome. Br J Dermatol. 2007;156:1089–1090
  15. Freyschmidt-Paul P, Hoffmann R, König A, Happle R. Linear porokeratosis superimposed on disseminated superficial actinic porokeratosis: report of two cases exemplifying the concept of type 2 segmental manifestation of autosomal dominant skin disorders. J Am Acad Dermatol. 1999;41:644–647
  16. Bloom D, Abramowitz EW. Porokeratosis Mibelli: report of three cases in one family; histologic studies. Arch Dermatol Syph. 1943;47:1–15
  17. MacMillan AL, Roberts SOB. Porokeratosis of Mibelli after renal transplantation. Br J Dermatol. 1974;90:45–51
  18. Pearson IC, Cliff S. Case 6: Linear porokeratosis with disseminated superficial porokeratosis erupting in pregnancy. Clin Exp Dermatol. 2003;28:345–346
  19. Goebeler M, Bröcker EB, Hamm H. Keratotic plaques on the left trunk area and all extremities: porokeratosis with clinical manifestations of both linear porokeratosis (LP) and disseminated superficial actinic porokeratosis (DSAP). Arch Dermatol. 2006;142:60–6163-4
  20. Suárez-Amor O, Pereiro-Ferreirós M, Ginarte M, Peteiro C, Toribio J. Coexistence of linear porokeratosis and disseminated superficial actinic porokeratosis: a type 2 segmental manifestation. Acta Derm Venereol. 2007;87:363–364
  21. Hanumanthayya K, Magavi S, Tophakhane R, Rathod R. Coexistence of disseminated superficial and giant porokeratosis of Mibelli with squamous cell carcinoma. Indian J Dermatol Venereol Leprol. 2003;69:296–297
  22. Bozdağ KE, Bıçakçı H, Ermete M. Giant porokeratosis. Int J Dermatol. 2004;43:518–520

 Funding sources: None.

 Conflicts of interest: None declared.

PII: S0190-9622(09)00073-5

doi: 10.1016/j.jaad.2008.12.049

Journal of the American Academy of Dermatology
Volume 62, Issue 1 , Pages 136-138 , January 2010

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