Follicular mucinosis: Clinical, histologic, and molecular remission with minocycline

Follicular mucinosis is an uncommon inflammatory disorder characterized histologically by mucin accumulation in the follicular epithelium. The condition is generally divided into primary and secondary forms, the latter being frequently associated with mycosis fungoides. Lesional skin T-cell clonality has been documented in some patients with follicular mucinosis, even those with no histologic evidence of cutaneous lymphoma. In this report, we describe a patient with clonal idiopathic primary follicular mucinosis who had complete clinical, histologic, and molecular remission with minocycline therapy.

Key words: clonality, follicular mucinosis, minocycline, therapy

Abbreviations used: CTCL, cutaneous T-cell lymphoma, FM, follicular mucinosis, MF, mycosis fungoides, TCR, T-cell receptor