Journal of the American Academy of Dermatology
Volume 62, Issue 2 , Pages 300-307 , February 2010

Primary cutaneous aggressive epidermotropic CD8+ T-cell lymphoma

  • Rachel H. Gormley, BS

      Affiliations

    • Department of Dermatology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania
    • ,
  • Stephen D. Hess, MD, PhD

      Affiliations

    • Department of Dermatology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania
    • ,
  • Dipti Anand, MD

      Affiliations

    • Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania
    • ,
  • Jacqueline Junkins-Hopkins, MD

      Affiliations

    • Department of Dermatology, The Johns Hopkins School of Medicine, Baltimore, Maryland
    • ,
  • Alain H. Rook, MD

      Affiliations

    • Department of Dermatology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania
    • ,
  • Ellen J. Kim, MD

      Affiliations

    • Department of Dermatology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania
    • Corresponding Author InformationReprint requests: Ellen J. Kim, MD, Hospital of the University of Pennsylvania, Perelman Center for Advanced Medicine, 1st Floor, Suite 3305, 3400 Civic Ctr Blvd, 3400 Spruce St, Philadelphia, PA 19104.

References 

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  2. Willemze R, Kerl H, Sterry W, Berti E, Cerroni L, Chimenti S, et al. EORTC classification for primary cutaneous lymphomas: a proposal from the cutaneous lymphoma study group of the European Organization for Research and Treatment of Cancer. Blood. 1997;90:354–371
  3. Berti E, Tomasini D, Vermeer MH, Meijer CJ, Alessi E, Willemze R. Primary cutaneous CD8-positive epidermotropic cytotoxic T cell lymphomas: a distinct clinicopathological entity with an aggressive clinical behavior. Am J Pathol. 1999;155:483–492
  4. Agnarsson BA, Vonderheid EC, Kadin ME. Cutaneous T cell lymphoma with suppressor/cytotoxic (CD8) phenotype: identification of rapidly progressive and chronic subtypes. J Am Acad Dermatol. 1990;22:569–577
  5. Marzano AV, Ghislanzoni M, Gianelli U, Caputo R, Alessi E, Berti E. Fatal CD8+ epidermotropic cytotoxic primary cutaneous T-cell lymphoma with multiorgan involvement. Dermatology. 2005;211:281–285
  6. Kim YH, Willemze R, Pimpinelli N, Whittaker S, Olsen EA, Ranki A, et al. TNM classification system for primary cutaneous lymphomas other than mycosis fungoides and Sezary syndrome: a proposal of the International Society for Cutaneous Lymphomas (ISCL) and the cutaneous lymphoma task force of the European Organization of Research and Treatment of Cancer (EORTC). Blood. 2007;110:479–484
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  8. Santucci M, Pimpinelli N, Massi D, Kadin ME, Meijer CJ, Muller-Hermelink HK, et al. Cytotoxic/natural killer cell cutaneous lymphomas: report of EORTC cutaneous lymphoma task force workshop. Cancer. 2003;97:610–627
  9. Quarterman MJ, Lesher JL, Davis LS, Pantazis CG, Mullins S. Rapidly progressive CD8-positive cutaneous T-cell lymphoma with tongue involvement. Am J Dermatopathol. 1995;17:287–291
  10. Kim SK, Kim YC, Kang HY. Primary cutaneous aggressive epidermotropic CD8(+) cytotoxic T-cell lymphoma with atypical presentation. J Dermatol. 2006;33:632–634
  11. Massone C, Chott A, Metze D, Kerl K, Citarella L, Vale E, et al. Subcutaneous, blastic natural killer (NK), NK/T-cell, and other cytotoxic lymphomas of the skin: a morphologic, immunophenotypic, and molecular study of 50 patients. Am J Surg Pathol. 2004;28:719–735
  12. Urrutia S, Piris MA, Orradre JL, Martinez B, Cruz MA, Garcia-Almagro D. Cytotoxic/suppressor (CD8+, CD4–) cutaneous T-cell lymphoma with aggressive course. Am J Dermatopathol. 1990;12:603–606
  13. Gelfand JM, Wasik MA, Vittorio C, Rook A, Junkins-Hopkins JM. Progressive epidermotropic CD8+/CD4– primary cutaneous CD30+ lymphoproliferative disorder in a patient with sarcoidosis. J Am Acad Dermatol. 2004;51:304–308
  14. Fika Z, Karkos PD, Badran K, Williams RE. Primary cutaneous aggressive epidermotropic CD8 positive cytotoxic T-cell lymphoma of the ear. J Laryngol Otol. 2007;121:503–505
  15. Kreuter A, Altmeyer P. Rapid onset of CD8+ aggressive T-cell lymphoma during bexarotene therapy in a patient with Sezary syndrome. J Am Acad Dermatol. 2005;53:1093–1095
  16. Introcaso CE, Kim EJ, Gardner J, Junkins-Hopkins JM, Vittorio CC, Rook AH. CD8+ epidermotropic cytotoxic T-cell lymphoma with peripheral blood and central nervous system involvement. Arch Dermatol. 2008;144:1027–1029
  17. Csomor J, Bognar A, Benedek S, Sinko J, Fekete S, Krenacs L, et al. Rare provisional entity: primary cutaneous aggressive epidermotropic CD8+ cytotoxic T-cell lymphoma in a young woman. J Clin Pathol. 2008;61:770–772
  18. Bekkenk MW, Vermeer MH, Jansen PM, van Marion AM, Canninga-van Dijk MR, Kluin PM, et al. Peripheral T-cell lymphomas unspecified presenting in the skin: analysis of prognostic factors in a group of 82 patients. Blood. 2003;102:2213–2219
  19. Guitart J, Gerami P. Cutaneous cytotoxic T-cell lymphomas workshop. Presented at: Department of Dermatology, Northwestern University; June 13, 2008; Chicago, IL.
  20. Kikuchi A, Sakuraoka K, Kurihara S, Akiyama M, Shimizu H, Nishikawa T. CD8+ cutaneous anaplastic large-cell lymphoma: report of two cases with immunophenotyping, T-cell-receptor gene rearrangement and electron microscopic studies. Br J Dermatol. 1992;126:404–408
  21. Dummer R, Kamarashev J, Kempf W, Haffner AC, Hess-Schmid M, Burg G. Junctional CD8+ cutaneous lymphomas with nonaggressive clinical behavior: a CD8+ variant of mycosis fungoides?. Arch Dermatol. 2002;138:199–203
  22. Hivnor CM, Nguyen V, Rook AH, Junkins-Hopkins J, Gelfand JM, Nasta S, et al. CD8+ lymphoma in a patient with human immunodeficiency virus. Arch Dermatol. 2005;141:1321–1322
  23. Introcaso CE, Leber B, Greene K, Ubriani R, Rook AH, Kim EJ. Stem cell transplantation in advanced cutaneous T-cell lymphoma. J Am Acad Dermatol. 2008;58:645–649
  24. Wenzel J, Gutgemann I, Distelmaier M, Uerlich M, Mikus S, Bieber T, et al. The role of cytotoxic skin-homing CD8+ lymphocytes in cutaneous cytotoxic T-cell lymphoma and pityriasis lichenoides. J Am Acad Dermatol. 2005;53:422–427

 Funding sources: None.

 Conflicts of interest: None declared.

PII: S0190-9622(09)00249-7

doi: 10.1016/j.jaad.2009.02.035

Journal of the American Academy of Dermatology
Volume 62, Issue 2 , Pages 300-307 , February 2010

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