Treatment of subcutaneous phaeohyphomycosis and prospective follow-up of 17 kidney transplant recipients
Accepted 3 March 2009. published online 09 October 2009.
Background
Subcutaneous phaeohyphomycosis in solid organ recipients may have an adverse outcome.
Objective
We sought to describe the disease course, treatment, and outcome of allograft function in kidney transplant recipients with phaeohyphomycosis.
Methods
Seventeen patients were followed for a mean period of 25.4 months to analyze the clinical response to treatment.
Results
There was no treatment failure or relapsing disease among 12 patients who completed treatment. Two patients were still in treatment with disease remission. One patient discontinued the study during treatment with partial remission, one died after finishing treatment with disease remission, and one was dropped from the study because contact was lost. Immunosuppressive regimens were not changed. Two of 17 patients had a significant reduction in allograft function.
Limitations
The follow-up time was short and the number of patients was small.
Conclusions
The outcome of phaeohyphomycosis in kidney transplant recipients was favorable with minimal impact on renal allograft function.
aDepartment of Dermatology, Federal University of São Paulo, São Paulo, Brazil
bDepartment of Medicine, Division of Nephrology, Federal University of São Paulo, São Paulo, Brazil
cDepartment of Medicine, Division of Infectious Diseases, Federal University of São Paulo, São Paulo, Brazil
dDivision of Cellular Biology, Federal University of São Paulo, São Paulo, Brazil
Reprint requests: José Osmar Medina-Pestana, MD, PhD, Hospital do Rim e Hipertensão, Rua Borges Lagoa 960, 11° andar, Vila Clementino, São Paulo - SP, Brazil. CEP: 04038-002.
Funding sources: None.
Conflicts of interest: None declared.
∗ Drs Ogawa and Galante contributed equally to this work and are both first authors.
ABSTRACT