Journal of the American Academy of Dermatology
Volume 61, Issue 6 , Pages 993-1000 , December 2009

Clinical, histopathologic, and immunophenotypic features of lymphomatoid papulosis with CD8 predominance in 14 pediatric patients

,Accepted 14 May 2009.

References 

  1. Macaulay WL. Lymphomatoid papulosis: a continuing self-healing eruption, clinically benign–histologically malignant. Arch Dermatol. 1968;97:23–30
  2. Bories N, Thomas L, Phan A, Balme B, Salameire D, Thurot-Guillou C, et al. Lymphomatoid papulosis in childhood: six case reports and a literature review. [in French] Ann Dermatol Venereol. 2008;135:657–662
  3. Slater DN. The new World Health Organization-European Organization for Research and Treatment of Cancer classification for cutaneous lymphomas: a practical marriage of two giants. Br J Dermatol. 2005;153:874–880
  4. Nijsten T, Curiel-Lewandrowski C, Kadin ME. Lymphomatoid papulosis in children: a retrospective cohort study of 35 cases. Arch Dermatol. 2004;140:306–312
  5. el-Azhary RA, Gibson LE, Kurtin PJ, Pittelkow MR, Muller SA. Lymphomatoid papulosis: a clinical and histopathologic review of 53 cases with leukocyte immunophenotyping, DNA flow cytometry, and T-cell receptor gene rearrangement studies. J Am Acad Dermatol. 1994;30:210–218
  6. Sanchez NP, Pittelkow MR, Muller SA, Banks PM, Winkelmann RK. The clinicopathologic spectrum of lymphomatoid papulosis: study of 31 cases. J Am Acad Dermatol. 1983;8:81–94
  7. Zirbel GM, Gellis SE, Kadin ME, Esterly NB. Lymphomatoid papulosis in children. J Am Acad Dermatol. 1995;33:741–748
  8. Van Neer FJ, Toonstra J, Van Voorst Vader PC, Willemze R, Van Vloten WA. Lymphomatoid papulosis in children: a study of 10 children registered by the Dutch cutaneous lymphoma working group. Br J Dermatol. 2001;144:351–354
  9. Ghiggeri GM, Bleid D, Garaventa A, Coccia C, Gambini C, Caridi G, et al. Recurrent lymphomatoid papulosis associated with nephrotic syndrome: an occurrence of uncertain origin. Pediatr Nephrol. 2009;24:189–192
  10. Aoki E, Aoki M, Kono M, Kawana S. Two cases of lymphomatoid papulosis in children. Pediatr Dermatol. 2003;20:146–149
  11. Hellman J, Phelps RG, Baral J, Fasy TM, Ahern CM, Strauchen JA. Lymphomatoid papulosis with antigen deletion and clonal rearrangement in a 4-year-old boy. Pediatr Dermatol. 1990;7:42–47
  12. Magro CM, Crowson AN, Morrison C, Merati K, Porcu P, Wright ED. CD8+ lymphomatoid papulosis and its differential diagnosis. Am J Clin Pathol. 2006;125:490–501
  13. Weinstein A, Mirzabeigi M, Withee M, Vincek V. Lymphomatoid papulosis in an HIV-positive man. AIDS Patient Care STDS. 2004;18:563–567
  14. Berti E, Tomasini D, Vermeer MH, Meijer CJ, Alessi E, Willemze R. Primary cutaneous CD8-positive epidermotropic cytotoxic T cell lymphomas: a distinct clinicopathological entity with an aggressive clinical behavior. Am J Pathol. 1999;155:483–492
  15. Gellrich S, Wilks A, Lukowsky A, Wernicke M, Muller A, Marcus Muche J, et al. T cell receptor-gamma gene analysis of CD30+ large atypical individual cells in CD30+ large primary cutaneous T cell lymphomas. J Invest Dermatol. 2003;120:670–675
  16. Magro CM, Nuovo GJ, Crowson AN. The utility of the in situ detection of T-cell receptor beta rearrangements in cutaneous T-cell-dominant infiltrates. Diagn Mol Pathol. 2003;12:133–141
  17. Kazakov DV, Kutzner H, Palmedo G, Boudova L, Michaelis S, Michal M, et al. Primary cutaneous lymphoproliferative disorders with dual lineage rearrangement. Am J Dermatopathol. 2006;28:399–409
  18. Boulland ML, Wechsler J, Bagot M, Pulford K, Kanavaros P, Gaulard P. Primary CD30-positive cutaneous T-cell lymphomas and lymphomatoid papulosis frequently express cytotoxic proteins. Histopathology. 2000;36:136–144
  19. Kummer JA, Vermeer MH, Dukers D, Meijer CJ, Willemze R. Most primary cutaneous CD30-positive lymphoproliferative disorders have a CD4-positive cytotoxic T-cell phenotype. J Invest Dermatol. 1997;109:636–640
  20. El-Shabrawi-Caelen L, Cerroni L, Medeiros LJ, McCalont TH. Hypopigmented mycosis fungoides: frequent expression of a CD8+ T+cell phenotype. Am J Surg Pathol. 2002;26:450–457
  21. Jang KA, Choi JC, Choi JH. Expression of cutaneous lymphocyte-associated antigen and TIA-1 by lymphocytes in pityriasis lichenoides et varioliformis acuta and lymphomatoid papulosis: immunohistochemical study. J Cutan Pathol. 2001;28:453–459
  22. Varga FJ, Vonderheid EC, Olbricht SM, Kadin ME. Immunohistochemical distinction of lymphomatoid papulosis and pityriasis lichenoides et varioliformis acuta. Am J Pathol. 1990;136:979–987
  23. Kadin ME. Characteristic immunologic profile of large atypical cells in lymphomatoid papulosis: possible implications for histogenesis and relationship to other diseases. Arch Dermatol. 1986;122:1388–1390
  24. Dupont A. La longue evolution d'une reticulose papuleuse apparement benigne et sa transformation malinge tardive. Bull Soc Fr Dermatol Syph. 1973;80:153–154
  25. Dupont A. Very late malignant transformation of papular reticulosis with a prolonged development (lymphomatoid papulosis). [in French] Ann Dermatol Syph (Paris). 1973;100:141–146
  26. Weinman VF, Ackerman AB. Lymphomatoid papulosis: a critical review and new findings. Am J Dermatopathol. 1981;3:129–163

 Funding sources: None.

 Conflicts of interest: None declared.

PII: S0190-9622(09)00616-1

doi: 10.1016/j.jaad.2009.05.014

Journal of the American Academy of Dermatology
Volume 61, Issue 6 , Pages 993-1000 , December 2009