Journal of the American Academy of Dermatology
Volume 62, Issue 2 , Pages 315-318, February 2010

Minocycline-induced drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome with persistent myocarditis

  • Kerry K. Shaughnessy, BA

      Affiliations

    • Department of Dermatology, Eastern Virginia Medical School, Norfolk, Virginia
    • ,
  • Susan M. Bouchard, BA

      Affiliations

    • Department of Dermatology, Eastern Virginia Medical School, Norfolk, Virginia
    • ,
  • Melinda R. Mohr, MD

      Affiliations

    • Department of Dermatology, Eastern Virginia Medical School, Norfolk, Virginia
    • Corresponding Author InformationCorrespondence to: Melinda R. Mohr, MD, Eastern Virginia Medical School, Department of Dermatology, 721 Fairfax Ave, Suite 200, Norfolk, VA 23507.
    • ,
  • John M. Herre, MD

      Affiliations

    • Department of Internal Medicine, Division of Cardiology, Eastern Virginia Medical School, Norfolk, Virginia
    • Sentara Cardiovascular Research Institute, Norfolk, Virginia
    • ,
  • Kimberly S. Salkey, MD

      Affiliations

    • Department of Dermatology, Eastern Virginia Medical School, Norfolk, Virginia

published online 10 August 2009.

Drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome is a rare serious adverse effect associated with a variety of medications. We present a case of minocycline-induced DRESS syndrome, which resulted in acute renal failure, transient thyroiditis, and transaminitis, and a persistent lymphocytic myocarditis resulting in congestive heart failure. To our knowledge, this is the third reported case of minocycline-induced myocarditis. Additionally, we report successful plasmapheresis and rituximab treatment for minocycline-induced myocarditis associated with the DRESS syndrome.

Key words: drug reaction, drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome, hypersensitivity syndrome, myocarditis

Abbreviations used: ANA, antinuclear antibody, CMV, cytomegalovirus, DRESS, drug reaction with eosinophilia and systemic symptoms, EBV, Epstein-Barr virus, HHV, human herpesvirus 6, HIV, human immunodeficiency virus

 

 Funding sources: None.

 Conflicts of interest: None declared.

 Reprints not available from the authors.

PII: S0190-9622(09)00692-6

doi:10.1016/j.jaad.2009.05.046

Journal of the American Academy of Dermatology
Volume 62, Issue 2 , Pages 315-318, February 2010