Journal of the American Academy of Dermatology
Volume 62, Issue 2 , Pages 315-318 , February 2010

Minocycline-induced drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome with persistent myocarditis

  • Kerry K. Shaughnessy, BA

      Affiliations

    • Department of Dermatology, Eastern Virginia Medical School, Norfolk, Virginia
    • ,
  • Susan M. Bouchard, BA

      Affiliations

    • Department of Dermatology, Eastern Virginia Medical School, Norfolk, Virginia
    • ,
  • Melinda R. Mohr, MD

      Affiliations

    • Department of Dermatology, Eastern Virginia Medical School, Norfolk, Virginia
    • Corresponding Author InformationCorrespondence to: Melinda R. Mohr, MD, Eastern Virginia Medical School, Department of Dermatology, 721 Fairfax Ave, Suite 200, Norfolk, VA 23507.
    • ,
  • John M. Herre, MD

      Affiliations

    • Department of Internal Medicine, Division of Cardiology, Eastern Virginia Medical School, Norfolk, Virginia
    • Sentara Cardiovascular Research Institute, Norfolk, Virginia
    • ,
  • Kimberly S. Salkey, MD

      Affiliations

    • Department of Dermatology, Eastern Virginia Medical School, Norfolk, Virginia

References 

  1. Ganeva M, Gancheva T, Lazarova R, Troeva J, Baldaranov I, Vassilev I, et al. Carbamazepine-induced drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome: report of four cases and brief review. Int J Dermatol. 2008;47:853–860
  2. Yun SJ, Lee JB, Kim EJ, Quan G, Kim SJ, Won YH, et al. Drug rash with eosinophilia and systemic symptoms induced by valproate and carbamazepine: formation of circulating auto-antibody against 190-kDa antigen. Acta Derm Venereol. 2006;86:241–244
  3. Allam JP, Paus T, Reichel C, Bieber T, Novak N. DRESS syndrome associated with carbamazepine and phenytoin. Eur J Dermatol. 2004;14:339–342
  4. Lefebvre N, Forestier E, Farhi D, Mahsa MZ, Remy V, Lesens O, et al. Minocycline-induced hypersensitivity syndrome presenting with meningitis and brain edema: a case report. J Med Case Reports. 2007;1:22
  5. Christe C, Ricou F, Stoller R, Vogt N. Minocycline-induced pericardial effusion. Ann Pharmacother. 2000;34:875–877
  6. Parneix-Spake A, Bastuji-Garin S, Lobut JB, Erner J, Guyet-Rousset P, Revuz J, et al. Minocycline as possible cause of severe and protracted hypersensitivity drug reaction. Arch Dermatol. 1995;131:490–491
  7. Roca B, Calvo B, Ferrer D. Minocycline hypersensitivity reaction with acute respiratory distress syndrome. Intensive Care Med. 2003;29:338
  8. Lee CW, Mitchell RN, Horan RF, Castells MC. Cardiogenic shock and peripheral eosinophilia in a young woman. Ann Allergy Asthma Immunol. 2005;95:229–233
  9. Burke AP, Saenger J, Mullick F, Virmani R. Hypersensitivity myocarditis. Arch Pathol Lab Med. 1991;115:764–769
  10. Garty BZ, Offer I, Livni E, Danon YL. Erythema multiforme and hypersensitivity myocarditis caused by ampicillin. Ann Pharmacother. 1994;28:730–731
  11. Colvin JH, Sheth AP. Minocycline hypersensitivity syndrome with hypotension mimicking septic shock. Pediatr Dermatol. 2001;18:295–298
  12. Abe M, Furukawa S, Takayama S, Michitaka K, Minami H, Yamamoto K, et al. Drug-induced hepatitis with autoimmune features during minocycline therapy. Intern Med. 2003;42:48–52
  13. Tsuruta D, Someda Y, Sowa J, Kobayashi H, Ishii M. Drug hypersensitivity syndrome caused by minocycline. J Cutan Med Surg. 2006;10:131–135
  14. Parc C, Brézin AP, Nataf I, Dusser D, Moachon L, D'Hermies F. Presumed hypersensitivity to minocycline and conjunctival infiltration. Br J Ophthalmol. 2002;86:1313–1314
  15. De Bolle L, Naesens L, De Clercq E. Update on human herpesvirus 6 biology, clinical features, and therapy. Clin Microbiol Rev. 2005;18:217–245
  16. Descamps V, Valance A, Edlinger C, Fillet AM, Grossin M, Lebrun-Vignes B, et al. Association of human herpesvirus 6 infection with drug reaction with eosinophilia and systemic symptoms. Arch Dermatol. 2001;137:301–304
  17. Eichenfield AH. Minocycline and autoimmunity. Curr Opin Pediatr. 1999;11:447–456
  18. Colglazier CL, Sutej PG. Laboratory testing in the rheumatic diseases: a practical review. South Med J. 2005;98:185–191
  19. Maubec E, Wolkenstein P, Loriot MA, Wechsler J, Mulot C, Beaune P, et al. Minocycline-induced DRESS: evidence for accumulation of the culprit drug. Dermatology. 2008;216:200–204
  20. Muller P, Dubreil P, Mahé A, Lamaury I, Salzer B, Deloumeaux J, et al. Drug Hypersensitivity Syndrome in a West-Indian population. Eur J Dermatol. 2003;13:478–481
  21. Smith K, Leyden JJ. Safety of doxycycline and minocycline: a systematic review. Clin Ther. 2005;27:1329–1342

 Funding sources: None.

 Conflicts of interest: None declared.

 Reprints not available from the authors.

PII: S0190-9622(09)00692-6

doi: 10.1016/j.jaad.2009.05.046

Journal of the American Academy of Dermatology
Volume 62, Issue 2 , Pages 315-318 , February 2010

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