Journal of the American Academy of Dermatology
Volume 62, Issue 3 , Pages 511-513 , March 2010

Decrease of ultraviolet A light–induced “common deletion” in healthy volunteers after oral Polypodium leucotomos extract supplement in a randomized clinical trial

  • Adriana Villa, MD

      Affiliations

    • Department of Dermatology and Cutaneous Surgery, University of Miami, Miller School of Medicine, Miami, Florida
    • ,
  • Martha H. Viera, MD

      Affiliations

    • Department of Dermatology and Cutaneous Surgery, University of Miami, Miller School of Medicine, Miami, Florida
    • ,
  • Sadegh Amini, MD

      Affiliations

    • Department of Dermatology and Cutaneous Surgery, University of Miami, Miller School of Medicine, Miami, Florida
    • ,
  • Ran Huo, MD

      Affiliations

    • Department of Dermatology and Cutaneous Surgery, University of Miami, Miller School of Medicine, Miami, Florida
    • ,
  • Oliver Perez, MD

      Affiliations

    • Department of Dermatology, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania
    • ,
  • Phillip Ruiz, MD, PhD

      Affiliations

    • Department of Dermatology and Cutaneous Surgery, University of Miami, Miller School of Medicine, Miami, Florida
    • ,
  • Alexandra Amador, PhD

      Affiliations

    • Department of Dermatology and Cutaneous Surgery, University of Miami, Miller School of Medicine, Miami, Florida
    • ,
  • George Elgart, MD

      Affiliations

    • Department of Dermatology and Cutaneous Surgery, University of Miami, Miller School of Medicine, Miami, Florida
    • ,
  • Brian Berman, MD, PhD

      Affiliations

    • Department of Dermatology and Cutaneous Surgery, University of Miami, Miller School of Medicine, Miami, Florida
    • Corresponding Author InformationCorrespondence to: Brian Berman, MD, PhD, Department of Dermatology and Cutaneous Surgery, University of Miami, Miller School of Medicine, 1600 NW 10th Ave, RSMB, Rm 2023A, Miami, FL 33136.

References 

  1. Philips N, Smith J, Keller T, Gonzalez S. Predominant effects of Polypodium leucotomos on membrane integrity, lipid peroxidation, and expression of elastin and matrixmetalloproteinase-1 in ultraviolet radiation exposed fibroblasts, and keratinocytes. J Dermatol Sci. 2003;32:1–9
  2. Berneburg M, Grether-Beck S, Kürten V, Ruzicka T, Briviba K, Sies H, et al. Singlet oxygen mediates the UVA-induced generation of the photoaging-associated mitochondrial common deletion. J Biol Chem. 1999;274:15345–15349
  3. Berneburg M, Plettenberg H, Medve-König K, Pfahlberg A, Gers-Barlag H, Gefeller O, et al. Induction of the photoaging-associated mitochondrial common deletion in vivo in normal human skin. J Invest Dermatol. 2004;122:1277–1283
  4. Gombau L, García F, Lahoz A, Fabre M, Roda-Navarro P, Majano P, et al. Polypodium leucotomos extract: antioxidant activity and disposition. Toxicol In Vitro. 2006;20:464–471
  5. Capote R, Alonso-Lebrero JL, García F, Brieva A, Pivel JP, González S. Polypodium leucotomos extract inhibits transurocanic acid photoisomerization and photodecomposition. J Photochem Photobiol B. 2006;82:173–179

 Supported by a 2008 Women's Dermatologic Society Academic Research Grant awarded to Adriana Villa, MD.

 Conflicts of interest: None declared.

PII: S0190-9622(09)00693-8

doi: 10.1016/j.jaad.2009.05.045

Journal of the American Academy of Dermatology
Volume 62, Issue 3 , Pages 511-513 , March 2010

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