Journal of the American Academy of Dermatology
Volume 61, Issue 6 , Pages 945-958, December 2009

Angiogenesis in cutaneous disease: Part II

  • Vivian Laquer, BS

      Affiliations

    • Columbia University College of Physicians, New York, New York
    • ,
  • Van Hoang, BS

      Affiliations

    • University of California Irvine College of Medicine, Irvine, California
    • ,
  • Amy Nguyen, MD

      Affiliations

    • Department of Dermatology, University of California, Irvine, California
    • ,
  • Kristen M. Kelly, MD

      Affiliations

    • Department of Dermatology, University of California, Irvine, California
    • University of California Irvine College of Medicine, Irvine, California
    • Corresponding Author InformationCorrespondence to: Kristen Kelly, MD, Department of Dermatology, University of California, Irvine, 1002 Health Sciences Rd, Irvine, CA 92612.

This review will discuss the role of angiogenesis in specific cutaneous diseases. Scientific evidence now points to the role of angiogenesis in tumor development and many other cutaneous disorders. Angiogenesis is a complex process that involves angiogenic growth factors and inhibitors, many of which could be a potential target for pharmacologic intervention. Antiangiogenic agents have recently been applied to dermatologic diseases with promising efficacy.

Learning objectives

After completing this learning activity, participants should be able to recognize cutaneous diseases where angiogenesis is likely to be an important factor, recognize scenarios where angiogenic therapy may be useful in conjunction with traditional therapies, and be able to use angiogenic-mediating agents in the treatment of dermatologic disease.

Key words: angiogenesis, antiangiogenic agents, dermatology

 

 Funding sources: None.

 Conflicts of interest: The authors, editors, and peer reviewers have no relevant financial relationships.

 Reprints not available from the authors.

PII: S0190-9622(09)00943-8

doi:10.1016/j.jaad.2009.05.053

Journal of the American Academy of Dermatology
Volume 61, Issue 6 , Pages 945-958, December 2009