Journal of the American Academy of Dermatology
Volume 62, Issue 3 , Pages 448-462 , March 2010

A randomized study of the efficacy and safety of injectable poly-L-lactic acid versus human-based collagen implant in the treatment of nasolabial fold wrinkles

  • Rhoda S. Narins, MD

      Affiliations

    • Department of Dermatology, New York University School of Medicine, New York, New York
    • Corresponding Author InformationReprint requests: Rhoda S. Narins, MD, Dermatology Surgery and Laser Center, 222 Westchester Ave, White Plains, NY 10604.
    • ,
  • Leslie Baumann, MD

      Affiliations

    • Division of Cosmetic Dermatology, University of Miami, Miami, Florida
    • ,
  • Fredric S. Brandt, MD

      Affiliations

    • private practice, Coral Gables, Florida
    • ,
  • Steven Fagien, MD

      Affiliations

    • private practice, Boca Raton, Florida
    • ,
  • Scott Glazer, MD

      Affiliations

    • private practice, Buffalo Grove, Illinois
    • ,
  • Nicholas J. Lowe, MD, FRCP

      Affiliations

    • Department of Dermatology, University of California-Los Angeles School of Medicine, Los Angeles, California
    • Clinical Research Specialists, Inc, Santa Monica, California
    • ,
  • Gary D. Monheit, MD

      Affiliations

    • Departments of Dermatology and Ophthalmology, University of Alabama at Birmingham, Birmingham, Alabama
    • ,
  • Marta I. Rendon, MD

      Affiliations

    • Dermatology and Aesthetic Center, Inc, Boca Raton, Florida
    • ,
  • Rod J. Rohrich, MD

      Affiliations

    • University of Texas Southwestern Medical Center, Dallas, Texas
    • ,
  • Wm. Philip Werschler, MD

      Affiliations

    • Medicine/Dermatology, University of Washington School of Medicine, Seattle, Washington
    • Premier Clinical Research, Spokane, Washington

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 Sponsored by Dermik Laboratories, a business of sanofi-aventis U.S. LLC. Editorial support for this article was also provided by Dermik Laboratories, a business of sanofi-aventis U.S. LLC, and by the editorial staff at Medicus International and Embryon.

 Disclosure: Drs Narins, Baumann, Fagien, Glazer, and Monheit were consultants for Dermik Laboratories, a business of sanofi-aventis U.S. LLC, during the time of the study. Dr Brandt receives grant support from Dermik Laboratories, a business of sanofi-aventis U.S. LLC. Dr Lowe was a consultant for and received grant support from Dermik Laboratories, a business of sanofi-aventis U.S. LLC, during the time of the study. Dr Rendon is a consultant for and receives grant support from Dermik Laboratories, a business of sanofi-aventis U.S. LLC. In addition, Dr Rendon is an advisory board member for and receives grant support from BioForm Medical Inc. Dr Werschler was a consultant, investigator, advisory board member, and speaker for Dermik Laboratories, a business of sanofi-aventis U.S. LLC, during the time of the study. Dr Rohrich has no conflicts of interest to declare.

 Clinical trial registry: NCT00444210 (comparative study); NCT00444353 (long-term follow-up).

PII: S0190-9622(09)00962-1

doi: 10.1016/j.jaad.2009.07.040

Journal of the American Academy of Dermatology
Volume 62, Issue 3 , Pages 448-462 , March 2010

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