Journal of the American Academy of Dermatology
Volume 62, Issue 2 , Pages 277-283 , February 2010

Trichoadenoma of Nikolowski is a distinct neoplasm within the spectrum of follicular tumors

  • Iakov Shimanovich, MD

      Affiliations

    • Department of Dermatology, University of Lübeck, Lübeck, Germany
    • Corresponding Author InformationReprint requests: Iakov Shimanovich, MD, Department of Dermatology, University of Lübeck, Ratzeburger Allee 160, 23538 Lübeck, Germany.
    • ,
  • Dieter Krahl, MD

      Affiliations

    • Institute for Dermatohistology, Heidelberg, Germany
    • ,
  • Christian Rose, MD

      Affiliations

    • Department of Dermatology, University of Lübeck, Lübeck, Germany

References 

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  2. Nikolowski W. Trichoadenom. Z Hautkr. 1978;53:87–90
  3. Reibold R, Undeutsch W, Fleiner J. Trichoadenoma of Nikolowski – review of four decades and seven new cases. Hautarzt. 1998;49:925–928
  4. Rahbari H, Mehregan A, Pinkus H. Trichoadenoma of Nikolowski. J Cutan Pathol. 1977;4:90–98
  5. Undeutsch W, Rassner G. Das Trichoadenom (Nikolowski). Ein klinischer und histologischer Fallbericht. Hautarzt. 1984;35:650–652
  6. Ackerman AB, Reddy VB, Soyer HP. Trichoadenoma. In: Neoplasms with follicular differentiation. 2nd ed. New York: Ardor Scribendi; 2001;p. 209–219
  7. Weedon D. Trichoadenoma. In: Skin pathology. 2nd ed. London: Churchill-Livingstone; 2002;p. 860–861
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  12. McCalmont TH. Trichoadenoma. In:  Bolognia JL,  Jorizzo J,  Rapini RP editor. Dermatology. 2nd ed. Elsevier; 2008;p. 1701
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  16. Kurokawa I, Mizutani H, Nishijima S, Kato N, Yasui K, Tsubura A. Trichoadenoma: cytokeratin expression suggesting differentiation towards the follicular infundibulum and follicular bulge regions. Br J Dermatol. 2005;153:1084–1088
  17. Hartschuh W, Weihe E. Multiple messenger candidates and marker substances in the mammalian Merkel cell-axon complex: a light and electron microscopic immunohistochemical study. Prog Brain Res. 1988;74:181–187
  18. Schulz T, Hartschuh W. Merkel cells are absent in basal cell carcinomas but frequently found in trichoblastomas: an immunohistochemical study. J Cutan Pathol. 1997;24:14–24
  19. Hartschuh W, Schulz T. Immunohistochemical investigation of the different developmental stages of trichofolliculoma with special reference to the Merkel cell. Am J Dermatopathol. 1999;21:8–15
  20. Hartschuh W, Schulz T. Merkel cells are integral constituents of desmoplastic trichoepithelioma: an immunohistochemical and electron microscopic study. J Cutan Pathol. 1995;22:413–421
  21. Abesamis-Cubillan E, El-Shabrawi-Caelen L, LeBoit PE. Merkel cells and sclerosing epithelial neoplasms. Am J Dermatopathol. 2000;22:311–315
  22. Katona TM, Perkins SM, Billings SD. Does the panel of cytokeratin 20 and androgen receptor antibodies differentiate desmoplastic trichoepithelioma from morpheaform/infiltrative basal cell carcinoma?. J Cutan Pathol. 2008;35:174–179
  23. Costache M, Bresch M, Böer A. Desmoplastic trichoepithelioma versus morphoeic basal cell carcinoma: a critical reappraisal of histomorphological and immunhistochemical criteria for differentiation. Histopathology. 2008;53:865–876
  24. Latza U, Niedobitek G, Schwarting R, Nekarda H, Stein H. Ber-EP4: new monoclonal antibody which distinguishes epithelia from mesothelia. J Clin Pathol. 1990;43:213–219
  25. Tellechea O, Reis JP, Domingues JC, Baptista AP. Monoclonal antibody Ber-EP4 distinguishes basal-cell carcinoma from squamous-cell carcinoma of the skin. Am J Dermatopathol. 1993;15:452–455
  26. Sellheyer K, Krahl D. Ber-EP4 enhances the differential diagnostic accuracy of cytokeratin 7 in pagetoid cutaneous neoplasms. J Cutan Pathol. 2008;35:366–372
  27. Swanson PE, Fitzpatrick MM, Ritter JH, Glusac EJ, Wick MR. Immunohistologic differential diagnosis of basal cell carcinoma, squamous cell carcinoma, and trichoepithelioma in small cutaneous biopsy specimens. J Cutan Pathol. 1998;25:153–159
  28. Krahl D, Sellheyer K. Monoclonal antibody Ber-EP4 reliably discriminates between microcystic adnexal carcinoma and basal cell carcinoma. J Cutan Pathol. 2007;34:782–787
  29. Gao W, Bohl C, Dalton J. Chemistry and structural biology of androgen receptor. Chem Rev. 2005;105:3352–3370
  30. Bayer-Garner I, Givens V, Smoller B. Immunohistochemical staining for androgen receptors: a sensitive marker of sebaceous differentiation. Am J Dermatopathol. 1999;21:426–431
  31. Izikson L, Bhan A, Zembowicz A. Androgen receptor expression helps to differentiate basal cell carcinoma from benign trichoblastic tumors. Am J Dermatopathol. 2005;27:91–95
  32. Katona TM, Ravis SM, Perkins SM, Moores WB, Billings SD. Expression of androgen receptor by fibroepithelioma of Pinkus: evidence supporting classification as a basal cell carcinoma variant?. Am J Dermatopathol. 2007;29:7–12

 Funding sources: None.

 Conflicts of interest: None declared.

PII: S0190-9622(09)00964-5

doi: 10.1016/j.jaad.2009.06.086

Journal of the American Academy of Dermatology
Volume 62, Issue 2 , Pages 277-283 , February 2010

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