Journal of the American Academy of Dermatology
Volume 63, Issue 2 , Pages 266-273 , August 2010

Long-term follow-up study of clear cell papulosis

  • Fang-Wen Tseng, MD

      Affiliations

    • Department of Dermatology, Chang Gung Memorial Hospital, Taipei, Taiwan
    • ,
  • Tseng-Tong Kuo, MD, PhD

      Affiliations

    • Department of Pathology, Chang Gung Memorial Hospital, Taipei, Taiwan
    • Chang Gung University College of Medicine, Taipei, Taiwan
    • ,
  • Pei-Hsuan Lu, MD

      Affiliations

    • Department of Dermatology, Chang Gung Memorial Hospital, Taipei, Taiwan
    • Chang Gung University College of Medicine, Taipei, Taiwan
    • ,
  • Heng-Leong Chan, MD

      Affiliations

    • Department of Dermatology, Sutein Clinic, Taipei, Taiwan
    • ,
  • Ming-Jing Chan, MD

      Affiliations

    • Department of Dermatology, Chang Gung Memorial Hospital, Taipei, Taiwan
    • Chang Gung University College of Medicine, Taipei, Taiwan
    • ,
  • Rosaline Chung-Yee Hui, MD, PhD

      Affiliations

    • Department of Dermatology, Chang Gung Memorial Hospital, Taipei, Taiwan
    • Chang Gung University College of Medicine, Taipei, Taiwan
    • Corresponding Author InformationReprint requests: Rosaline Chung-Yee Hui, MD, PhD, Department of Dermatology, Chang Gung Memorial Hospital, No. 199, Tung-Hwa North Road, Taipei, Taiwan.

,Accepted 14 August 2009.

References 

  1. Kuo TT, Chan HL, Hsueh S. Clear cell papulosis of the skin: a new entity with histogenetic implications for cutaneous Paget's disease. Am J Surg Pathol. 1987;11:827–834
  2. Kuo TT, Huang CL, Chan HL, Yang LJ, Chen MJ. Clear cell papulosis: report of three cases of a newly recognized disease. J Am Acad Dermatol. 1995;33:230–233
  3. Kim YC, Bang D, Cinn YW. Clear cell papulosis: case report and literature review. Pediatr Dermatol. 1997;14:380–382
  4. Lee JY. Clear cell papulosis: a unique disorder in early childhood characterized by white macules in milk-line distribution. Pediatr Dermatol. 1998;15:328–329
  5. Lee JY, Chao SC. Clear cell papulosis of the skin. Br J Dermatol. 1998;138:678–683
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  9. Chong WS, Ong BH, Kumarasinghe SP. Hypopigmented papules in an Asian boy. Pediatr Dermatol. 2005;22:268–269
  10. Benouni S, Kos L, Ruggeri SY, North PE, Drolet BA. Clear cell papulosis in Hispanic siblings. Arch Dermatol. 2007;143:358–360
  11. Kim YC, Mehregan DA, Bang D. Clear cell papulosis: an immunohistochemical study to determine histogenesis. J Cutan Pathol. 2002;29:11–14
  12. van der Putte SC, Toonstra J, Hennipman A. Mammary Paget's disease confined to the areola and associated with multifocal Toker cell hyperplasia. Am J Dermatopathol. 1995;17:487–493
  13. Chen YH, Wong TW, Lee JY. Depigmented genital extramammary Paget's disease: a possible histogenetic link to Toker's clear cells and clear cell papulosis. J Cutan Pathol. 2001;28:105–108
  14. Marucci G, Betts CM, Golouh R, Peterse JL, Foschini MP, Eusebi V. Toker cells are probably precursors of Paget cell carcinoma: a morphological and ultrastructural description. Virchows Arch. 2002;441:117–123
  15. Willman JH, Golitz LE, Fitzpatrick JE. Clear cells of Toker in accessory nipples. J Cutan Pathol. 2003;30:256–260
  16. Willman JH, Golitz LE, Fitzpatrick JE. Vulvar clear cells of Toker: precursors of extramammary Paget's disease. Am J Dermatopathol. 2005;27:185–188
  17. Belousova IE, Kazakov DV, Michal M, Suster S. Vulvar Toker cells: the long-awaited missing link; a proposal for an origin-based histogenetic classification of extramammary Paget disease. Am J Dermatopathol. 2006;28:84–86
  18. Fernandez-Flores A. Toker-cell pathology as a unifying concept. Histopathology. 2008;52:889–892
  19. Toker C. Clear cells of the nipple epidermis. Cancer. 1970;25:601–610
  20. Di Tommaso L, Franchi G, Destro A, Broglia F, Minuti F, Rahal D, et al. Toker cells of the breast: morphological and immunohistochemical characterization of 40 cases. Hum Pathol. 2008;39:1295–1300
  21. Lundquist K, Kohler S, Rouse RV. Intraepidermal cytokeratin 7 expression is not restricted to Paget cells but is also seen in Toker cells and Merkel cells. Am J Surg Pathol. 1999;23:212–219

 Funding sources: None.

 Conflicts of interest: None declared.

PII: S0190-9622(09)01217-1

doi: 10.1016/j.jaad.2009.08.056

Journal of the American Academy of Dermatology
Volume 63, Issue 2 , Pages 266-273 , August 2010

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