Journal of the American Academy of Dermatology
Volume 62, Issue 3 , Pages 398-401 , March 2010

Commentary: Treatment of lichen planopilaris: Some progress, but a long way to go

  • Leonard C. Sperling, MD

      Affiliations

    • Department of Dermatology at Uniformed Services University of the Health Sciences, Bethesda, Maryland
    • Corresponding Author InformationCorrespondence to: Leonard C. Sperling, MD, Department of Dermatology, Uniformed Services University, 4301 Jones Bridge Rd, Bethesda, MD 20814.
    • ,
  • Jennifer V. Nguyen, MD

      Affiliations

    • Department of Dermatology, University of Pennsylvania, Philadelphia, Pennsylvania

References 

  1. Oxford Center for Evidence-based Medicine (2009). Oxford Centre for Evidence-based Medicine - Levels of Evidence. Available from: http://www.cebm.net. Accessed September 29, 2009.
  2. Chieregato C, Zini A, Barba A, Magnanini M, Rosina P. Lichen planopilaris: report of 30 cases and review of the literature. Int J Dermatol. 2003;42:342–345
  3. Mehregan DA, van Hale HM, Muller SA. Lichen planopilaris: clinical and pathologic study of forty-five patients. J Am Acad Dermatol. 1992;27:935–942
  4. Cevasco NC, Bergfeld WF, Remzi BK, de Knott HR. A case-series of 29 patients with lichen planopilaris: the Cleveland Clinic Foundation experience on evaluation, diagnosis, and treatment. J Am Acad Dermatol. 2007;57:47–53
  5. Assouly P, Reygagne P. Lichen planopilaris: update on diagnosis and treatment. Semin Cutan Med Surg. 2009;28:3–10
  6. Volz T, Caroli U, Lüdtke H, Bräutigam M, Kohler-Späth H, Röcken M, et al. Pimecrolimus cream 1% in erosive oral lichen planus–a prospective randomized double-blind vehicle-controlled study. Br J Dermatol. 2008;159:936–941
  7. Mirmirani P, Willey A, Price VH. Short course of oral cyclosporine in lichen planopilaris. J Am Acad Dermatol. 2003;49:667–671
  8. Blazek C, Megahed M. Lichen planopilaris: successful treatment with tacrolimus. [German]. Hautarzt. 2008;59:874–877
  9. Scalvenzi M, De Natale F, Forgione P, Russo N, Delfino M. Topical cyclosporin A in the treatment of lichen planopilaris. Ann Ital Dermatol Clin Sper. 1998;52:37–40
  10. Spencer LA, Hawryluk EB, English JC. Lichen planopilaris: retrospective study and stepwise therapeutic approach. Arch Dermatol. 2009;145:333–334
  11. Tan E, Martinka M, Ball N, Shapiro J. Primary cicatricial alopecias: clinicopathology of 112 cases. J Am Acad Dermatol. 2004;50:25–32
  12. Jouanique C, Reygagne P, Assouly P, Matard B, Marechal E, Bachelez H, et al. Hydroxychloroquine sulphate's ineffectiveness in the treatment of lichen planopilaris and idiopathic pseudopelade. Research abstract presented at: Third Intercontinental Meeting of Hair Research Societies; June 13-15, 2001; Tokyo, Japan.
  13. Bianchi L, Paro Vidolin A, Piemonte P, Carboni I, Chimenti S. Graham Little-Piccardi-Lassueur syndrome: effective treatment with cyclosporin A. Clin Exp Dermatol. 2001;26:518–520
  14. Boyd AS, King LE. Thalidomide-induced remission of lichen planopilaris. J Am Acad Dermatol. 2002;47:967–968
  15. Doherty SD, Hsu S. A case series of 48 patients treated with thalidomide. J Drugs Dermatol. 2008;7:769–773
  16. George SJ, Hsu S. Lichen planopilaris treated with thalidomide. J Am Acad Dermatol. 2001;45:965–966
  17. Jouanique C, Reygagne P, Bachelez H, Dubertret L. Thalidomide is ineffective in the treatment of lichen planopilaris. J Am Acad Dermatol. 2004;51:480–481
  18. Tursen U, Api H, Kaya T, Ikizoglu G. Treatment of lichen planopilaris with mycophenolate mofetil. Dermatol Online J. 2004;10:24
  19. Laurberg G, Geiger JM, Hjorth N, Holm P, Hou-Jensen K, Jacobsen KU, et al. Treatment of lichen planus with acitretin: a double-blind, placebo-controlled study in 65 patients. J Am Acad Dermatol. 1991;24:434–437
  20. Ott F, Bollag W, Geiger JM. Efficacy of oral low-dose tretinoin (all- trans-retinoic acid) in lichen planus. Dermatology. 1996;192:334–336
  21. Massa MC, Rogers RS. Griseofulvin therapy of lichen planus. Acta Derm Venereol. 1981;61:547–550
  22. Stefanidou MP, Ioannidou DJ, Panayiotides JG, Tosca AD. Low molecular weight heparin; a novel alternative therapeutic approach for lichen planus. Br J Dermatol. 1999;141:1040–1045
  23. Chiang C, Sah D, Cho BK, Ochoa BE, Price VH. Hydroxychloroquine and lichen planopilaris: efficacy and introduction of Lichen Planopilaris Activity Index scoring system. J Am Acad Dermatol. 2010;62:387–920
  24. Cho BK, Sah D, Chwalek J, Roseborough I, Ochoa BE, Chiang C, et al. Efficacy and safety of mycophenolate mofetil for lichen planopilaris. J Am Acad Dermatol. 2010;62:393–397

 Funding sources: None.

 Conflicts of interest: None declared.

 Reprints not available from the authors.

PII: S0190-9622(09)01356-5

doi: 10.1016/j.jaad.2009.10.025

Journal of the American Academy of Dermatology
Volume 62, Issue 3 , Pages 398-401 , March 2010

Article Tools