Journal of the American Academy of Dermatology
Volume 40, Issue 2 , Pages 200-203 , February 1999

Hormones and hair patterning in men: A role for insulin-like growth factor 1?

,Accepted 2 November 1998.

References 

  1. Thiboutot DM. Normal physiology of the pilosebaceous unit. In:  Azziz R,  Nestler JE,  Dewailly D editor. Androgen excess disorders in women. Philadelphia: Lippincott Raven; 1997;p. 103–115
  2. Parker F. Skin diseases. In: 19th ed.  Wyngarden JB,  Smith LH,  Bennett JC editor. Cecil Textbook of medicine. Philadelphia: WB Saunders; 1992;p. 2280–2296
  3. Demark-Wahnefried W, Lesko SM, Conaway MR, Robertson CN, Clark RV, Logaugh B, et al.  Serum androgens: associations with prostate cancer risk and hair patterning. J Androl. 1997;18:495–500
  4. Blok GJ, de Boer H, Gooren LJG, van der Veen EA. Growth hormone substitution in adult growth hormone–deficient men augments androgen effects on the skin. Clin Endocrinol. 1997;47:29–36
  5. Wolk A, Mantzoros CS, Andersson S-O, Signorello LB, Lagiou P, Bergstrom R, et al.  Insulin like growth factor 1 and prostate cancer risk: a population based case-control study. J Natl Cancer Inst. 1998;90:911–915
  6. Norwood OT. Male pattern baldness: classification and incidence. South Med J. 1975;68:1359–1365
  7. Ferriman D, Gallwey JD. Clinical assessment of body hair growth in women. J Clin Endocrinol Metab. 1961;24:1440–1447
  8. Kovacs WJ, Wilson JD. Hirsutism and virilization. In: 13th ed.  Isselbacher KJ,  Braunwald E,  Wilson JD,  Martin JD,  Fauci AS,  Kasper DL editor. Harrison’s Principles of internal medicine. New York: McGraw-Hill; 1994;p. 268–270
  9. Farthing MJG, Mattei AM, Edwards CRW, Dawson AM. Relationship between plasma testosterone and dihydrotestosterone concentrations and male facial hair growth. Br J Dermatol. 1982;107:559–564
  10. Zachmann M, Prader A. Anabolic and androgenic effect of testosterone in sexually immature boys and its dependency on growth hormone. J Clin Endocrinol Metab. 1970;30:85–95
  11. Randall VA. The role of androgens in the regulation of the human hair follicle. In:  Azziz R,  Nestler JE,  Dewailly D editor. Androgen excess disorders in women. Philadelphia: Lippincott Raven; 1997;p. 115–130
  12. Uno H. Biology of hair growth. Semin Reprod Endcrinol. 1986;4:131–141
  13. Shoham Z, Conway GS, Ostergaard H, Lahlou N, Bouchard P, Jacobs HS. Cotreatment with growth hormone for induction of spermatogenesis in patients with hypogonadotrophic hypogonadism. Fertil Steril. 1992;57:1044–1051
  14. Spiteri-Grech J, Nieschlag E. The role of growth hormone and insulin-like growth factor I in the regulation of male reproductive function. Horm Res. 1992;38(suppl 1):22–27
  15. Balducci R, Toscano V, Casilli D, Maroder M, Sciarra F, Boscherini B. Testicular responsiveness following chronic administration of hCG (1500 IU every six days) in untreated hypogonadotropic hypogonadism. Horm Metab Res. 1987;19:216–221
  16. Culig Z, Hobisch A, Cronauer MV, Radmayr C, Trapman J, Hittmair A, et al.  Androgen receptor activation in prostatic tumor cell lines by insulin-like growth factor-I, keratinocyte growth factor, and epidermal growth factor. Cancer Res. 1994;54:5474–5478
  17. Horton R, Pasupuletti V, Antonipillai I. Androgen induction of steroid 5 alpha-reductase may be mediated via insulin-like growth factor-I. Endocrinology. 1993;133:447–451

☆ Supported in Greece by a grant from the Europe Against Cancer program of the European Union, and in Boston by a grant to Harvard University from George S. Livanos. Lisa B. Signorello is supported by a training award in cancer epidemiology from the US National Institutes of Health, National Cancer Institute (5T32CA09001-21). Christos S. Mantzoros is supported by the Junior Investigator/Hershey Family Awards, Beth Israel Deaconess Medical Center and Harvard Medical School.

☆☆ Reprint requests: Dimitrios Trichopoulos, Department of Epidemiology and Harvard Center for Cancer Prevention, 677 Huntington Ave, Harvard School of Public Health, Boston, MA 02115

★ Correspondence and reprint requests: Christos S. Mantzoros, Division of Endocrinology, RN 325, Beth Israel Deaconess Medical Center, 99 Brookline Ave, Boston, MA 02215.

★★ 0190-9622/99/$8.00 + 0  16/1/95509

PII: S0190-9622(99)70188-X

Journal of the American Academy of Dermatology
Volume 40, Issue 2 , Pages 200-203 , February 1999

Article Tools